| Title: | Piezoresistive Membrane Surface Stress Sensors for Characterization of Breath Samples of Head and Neck Cancer Patients |
| Author(s): | Lang HP; Loizeau F; Hiou-Feige A; Rivals JP; Romero P; Akiyama T; Gerber C; Meyer E; |
| Address: | "Department of Physics, University of Basel, Swiss Nanoscience Institute, Klingelbergstrasse 82, CH-4056 Basel, Switzerland. Hans-Peter.Lang@unibas.ch. SAMLAB, EPFL Neuchâtel, CH-2002 Neuchâtel, Switzerland. frederic.loizeau@sensirion.com. Department of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, CH-1015 Lausanne, Switzerland. Agnes.Hiou@chuv.ch. Department of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, CH-1015 Lausanne, Switzerland. Jean-Paul.Rivals@chuv.ch. Ludwig Cancer Research Center, Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, CH-1066 Epalinges, Switzerland. Pedro.Romero@hospvd.ch. SAMLAB, EPFL Neuchâtel, CH-2002 Neuchâtel, Switzerland. akiyama@nanoworld.com. Department of Physics, University of Basel, Swiss Nanoscience Institute, Klingelbergstrasse 82, CH-4056 Basel, Switzerland. Christoph.Gerber@unibas.ch. Department of Physics, University of Basel, Swiss Nanoscience Institute, Klingelbergstrasse 82, CH-4056 Basel, Switzerland. Ernst.Meyer@unibas.ch" |
| ISSN/ISBN: | 1424-8220 (Electronic) 1424-8220 (Linking) |
| Abstract: | "For many diseases, where a particular organ is affected, chemical by-products can be found in the patient's exhaled breath. Breath analysis is often done using gas chromatography and mass spectrometry, but interpretation of results is difficult and time-consuming. We performed characterization of patients' exhaled breath samples by an electronic nose technique based on an array of nanomechanical membrane sensors. Each membrane is coated with a different thin polymer layer. By pumping the exhaled breath into a measurement chamber, volatile organic compounds present in patients' breath diffuse into the polymer layers and deform the membranes by changes in surface stress. The bending of the membranes is measured piezoresistively and the signals are converted into voltages. The sensor deflection pattern allows one to characterize the condition of the patient. In a clinical pilot study, we investigated breath samples from head and neck cancer patients and healthy control persons. Evaluation using principal component analysis (PCA) allowed a clear distinction between the two groups. As head and neck cancer can be completely removed by surgery, the breath of cured patients was investigated after surgery again and the results were similar to those of the healthy control group, indicating that surgery was successful" |
| Keywords: | "Aged Aged, 80 and over Biosensing Techniques/*methods Breath Tests Female Head and Neck Neoplasms/*diagnosis/surgery Humans Male Middle Aged Pilot Projects Principal Component Analysis breath analysis electronic nose head and neck cancer nanomechanical se;" |
| Notes: | "MedlineLang, Hans Peter Loizeau, Frederic Hiou-Feige, Agnes Rivals, Jean-Paul Romero, Pedro Akiyama, Terunobu Gerber, Christoph Meyer, Ernst eng Switzerland 2016/07/28 Sensors (Basel). 2016 Jul 22; 16(7):1149. doi: 10.3390/s16071149" |
