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Trends Endocrinol Metab

Title:		Olfactory system and energy metabolism: a two-way street
Author(s):		Jovanovic P; Riera CE;
Address:		"Center for Neural Science and Medicine, Biomedical Sciences Department and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 South San Vicente Boulevard, Los Angeles, CA 90048, USA. Center for Neural Science and Medicine, Biomedical Sciences Department and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 South San Vicente Boulevard, Los Angeles, CA 90048, USA; Department of Neurology, Cedars-Sinai Medical Center, Movement Disorder Program, 127 South San Vicente Boulevard, Los Angeles, CA 90048, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: Celine.riera@cshs.org"
Journal Title:		Trends Endocrinol Metab
Year:		2022
Volume:		20220214
Issue:		4
Page Number:		281 - 291
DOI:		10.1016/j.tem.2022.01.004
ISSN/ISBN:		1879-3061 (Electronic) 1043-2760 (Linking)
Abstract:		"Olfactory perception guides daily decisions regarding food consumption, social interactions, and predator avoidance in all mammalian species. Volatile inputs, comprising odorants and pheromones, are relayed to the olfactory bulb (OB) from nasal sensory neurons cells and transferred to secondary processing regions within the brain. Olfaction has recently been shown to shape homeostatic and maladaptive processes of energy intake and expenditure through neuronal circuits involving the medial basal hypothalamus. Reciprocally, gastrointestinal hormones, such as ghrelin and leptin, the secretion of which depends on satiety and adiposity levels, might also influence olfactory sensitivity to alter food-seeking behaviors. Here, in addition to reviewing recent updates on identifying these neuronal networks, we also discuss how bidirectional neurocircuits existing between olfactory and energy processing centers can become dysregulated during obesity"
Keywords:		Animals Energy Intake *Energy Metabolism Homeostasis Humans Mammals Obesity *Olfactory Bulb/physiology Smell/physiology arcuate nucleus hormonal feedback hypothalamus olfaction sensory perception thermogenesis;
Notes:		"MedlineJovanovic, Predrag Riera, Celine E eng Research Support, Non-U.S. Gov't Review 2022/02/19 Trends Endocrinol Metab. 2022 Apr; 33(4):281-291. doi: 10.1016/j.tem.2022.01.004. Epub 2022 Feb 14"