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J Breath Res

Title:		On-line breath analysis with PTR-TOF
Author(s):		Herbig J; Muller M; Schallhart S; Titzmann T; Graus M; Hansel A;
Address:		"Ionimed Analytik GmbH, Innsbruck, Austria"
Journal Title:		J Breath Res
Year:		2009
Volume:		20090609
Issue:		2
Page Number:		27004 -
DOI:		10.1088/1752-7155/3/2/027004
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"We report on on-line breath gas analysis with a new type of analytical instrument, which represents the next generation of proton-transfer-reaction mass spectrometers. This time-of-flight mass spectrometer in combination with the soft proton-transfer-reaction ionization (PTR-TOF) offers numerous advantages for the sensitive detection of volatile organic compounds and overcomes several limitations. First, a time-of-flight instrument allows for a measurement of a complete mass spectrum within a fraction of a second. Second, a high mass resolving power enables the separation of isobaric molecules and the identification of their chemical composition. We present the first on-line breath measurements with a PTR-TOF and demonstrate the advantages for on-line breath analysis. In combination with buffered end-tidal (BET) sampling, we obtain a complete mass spectrum up to 320 Th within one exhalation with a signal-to-noise ratio sufficient to measure down to pptv levels. We exploit the high mass resolving power to identify the main components in the breath composition of several healthy volunteers"
Keywords:
Notes:		"PubMed-not-MEDLINEHerbig, Jens Muller, Markus Schallhart, Simon Titzmann, Thorsten Graus, Martin Hansel, Armin eng England 2009/06/01 J Breath Res. 2009 Jun; 3(2):027004. doi: 10.1088/1752-7155/3/2/027004. Epub 2009 Jun 9"