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Regul Toxicol Pharmacol

Title:		Use of partition models to evaluate guidelines for mixtures of volatile organic compounds
Author(s):		Hau KM; Connell DW; Richardson BJ;
Address:		"School of Public Health, Logan, Queensland, Australia. hokmhau@polyu. edu.hk"
Journal Title:		Regul Toxicol Pharmacol
Year:		2000
Volume:		32
Issue:		1
Page Number:		36 - 41
DOI:		10.1006/rtph.2000.1405
ISSN/ISBN:		0273-2300 (Print) 0273-2300 (Linking)
Abstract:		"Partition models based on the octanol-air parition coefficients and associated quantitative structure-activity relationships (QSARs) have been developed to describe the triggering of odor response and nasal irritation by common volatile organic compounds (VOCs). This study made use of the QSARs developed by Hau and Connell (1998, Indoor Air 8, 23-33) and Hau et al. (1999, Toxicol. Sci. 47, 93-98) to evaluate risk-based guidelines on the airborne concentrations of common VOCs in the nonindustrial environment. A new concept referred to as the 'apparent internal threshold concentration' was developed for evaluating the odor and nasal pungency responses to a typical low-concentration VOC mixture described by Otto et al. (1990, Neurotoxicol. Teratol. 12, 649-652). The assessment indicated that odor can be detected at a total VOC concentration of about 3 mg/m(3), consistent with the findings of Molhave et al. (1991, Atmos. Environ. 25, 1283-1293). Nasal pungency, according to our assessment, should not ocur at a total concentration of 25 mg/m(3), which is apparently in conflict with the findings of Molhave (1986, ASHRAE Trans. 92(1A), 306-316). It can be inferred from this investigation that pure nasal pungency without the influence of odor is unlikely to result from exposure to low-concentration VOC mixtures typically found in the nonindustrial environment"
Keywords:		"Air Pollutants/chemistry Air Pollution, Indoor Dose-Response Relationship, Drug Guidelines as Topic/*standards Humans *Models, Chemical Odorants/analysis Organic Chemicals/adverse effects/*chemistry Perception Quantitative Structure-Activity Relationship;"
Notes:		"MedlineHau, K M Connell, D W Richardson, B J eng Evaluation Study Review Netherlands 2000/10/13 Regul Toxicol Pharmacol. 2000 Aug; 32(1):36-41. doi: 10.1006/rtph.2000.1405"