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Scand J Psychol

Title:		Bicuculline infusion into the accessory olfactory bulb facilitates the induction of maternal behavior in rats
Author(s):		Carretero MI; Segovia S; Gomez F; Del Cerro MC;
Address:		"Dept. de Psicobiologia, Univ. Nacional de Educacion a Distancia, Madrid, Spain Area 11, IMSALUD, Madrid, Spain"
Journal Title:		Scand J Psychol
Year:		2003
Volume:		44
Issue:		3
Page Number:		273 - 277
DOI:		10.1111/1467-9450.00345
ISSN/ISBN:		0036-5564 (Print) 0036-5564 (Linking)
Abstract:		"The GABAA antagonist bicuculline, intracranially infused into the accessory olfactory bulb (AOB), facilitated the expression of maternal behavior (MB) in virgin Wistar female rats. Behavioral effects were observed 24 hours after infusion and were injection dependent. Pheromonal stimuli, generated by the pups, are thought to exert an inhibitory effect on vomeronasal nuclei involved in MB in virgin rats. The present study investigated the possibility that a decrement in AOB output, resulting from long-term compensatory synaptic changes to chronic bicuculline infusion, would facilitate the expression of MB. The implications of our findings for the mechanisms involved in the induction of MB and the maternal experience effect are discussed"
Keywords:		"Animals Bicuculline/administration & dosage/*pharmacology Convulsants/administration & dosage/*pharmacology Female *Infusion Pumps Maternal Behavior/*drug effects Olfactory Bulb/*drug effects Rats Rats, Wistar;"
Notes:		"MedlineCarretero, M I Segovia, S Gomez, F Del Cerro, M C R eng Research Support, Non-U.S. Gov't England 2003/08/14 Scand J Psychol. 2003 Jul; 44(3):273-7. doi: 10.1111/1467-9450.00345"