| Title: | Volatile organic compound breath testing detects in-situ squamous cell carcinoma of bronchial and laryngeal regions and shows distinct profiles of each tumour |
| Author(s): | Fielding D; Hartel G; Pass D; Davis M; Brown M; Dent A; Agnew J; Dickie G; Ware RS; Hodge R; |
| Address: | "Department of Thoracic Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. Queensland Institute Medical Research Berghofer, Brisbane, Australia. Queensland Department of Health Forensic and Scientific Services, Brisbane, Australia. The Prince Charles Hospital, Brisbane, Australia. Department of Ear Nose and Throat, Royal Brisbane and Women's Hospital, Brisbane, Australia. Department of Radiation Oncology, Royal Brisbane and Women's Hospital, Brisbane, Australia. Griffith University, Menzies Health Institute Queensland, Brisbane, Australia" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Volatile organic compound (VOC) breath testing of lung and head and neck squamous cell carcinoma (SCC) has been widely studied, however little is known regarding VOC profiles of in-situ SCC. A prospective study of VOC in patients with histologically proven SCC, either in-situ or advanced, and controls. Breath samples were analysed using the E-nose Cyranose ((R))320 and by gas chromatography/mass spectroscopy. Predictive models were developed using bootstrap forest using all 32 sensors. Data from 55 participants was analysed: 42 SCC cases comprising 20 bronchial (10 in-situ, 10 advanced) and 22 laryngeal (12 in-situ, 10 advanced), and 13 controls. There were 32 (76%) male SCC cases with mean age 63.6 (SD = 9.5) compared with 11 (85%) male controls with mean age 61.9 (SD = 10.1). Predictive models for in situ cases had good sensitivity and specificity compared to controls (overall, 95% and 69%; laryngeal, 100% and 85%; bronchial, 77% and 80%). When distinguishing in-situ and advanced tumours, sensitivity and specificity 82% and 75% respectively. For different tumour types (bronchial versus advanced laryngeal) sensitivity and specificity were 100% and 80% respectively. VOCs isolated from in-situ cancers included some previously demonstrated in advanced cancers and some novel VOCs. In-situ bronchial and laryngeal cancer can be detected by VOC analysis. Distinction from normal controls and between the two tumour types could allow screening in high risk groups for these curable lesions" |
| Keywords: | "Breath Tests/*methods Bronchi/pathology Bronchial Neoplasms/*diagnosis Bronchoscopy Carcinoma in Situ/*diagnosis Carcinoma, Squamous Cell/*diagnosis Case-Control Studies Female Fluorescence Gas Chromatography-Mass Spectrometry Humans Laryngeal Neoplasms/*;" |
| Notes: | "MedlineFielding, David Hartel, Gunter Pass, David Davis, Mark Brown, Michael Dent, Annette Agnew, Julienne Dickie, Graeme Ware, Robert S Hodge, Robert eng England 2020/10/07 J Breath Res. 2020 Oct 6; 14(4):046013. doi: 10.1088/1752-7163/abb18a" |
