| Title: | Quality assessment of Succus Bambusae oral liquids based on gas chromatography/mass spectrometry fingerprints and chemometrics |
| Author(s): | Feng H; Li S; Hu Y; Zeng X; Qiu P; Li Y; Li W; Li Z; |
| Address: | "College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. State key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Hunan Zhengqing Pharmaceutical Group Co., Ltd, Huaihua, Hunan, China. College of Chemistry and Materials Engineering, Huaihua University, Huaihua, Hunan, China" |
| Journal Title: | Rapid Commun Mass Spectrom |
| ISSN/ISBN: | 1097-0231 (Electronic) 0951-4198 (Linking) |
| Abstract: | "RATIONALE: Succus Bambusae is consumed as a kind of herbal medicine and natural beverage in China. However, the current quality standards for Succus Bambusae are low and lack safety indicators, which makes it difficult to effectively guarantee its quality. Therefore, it is of great significance to study the identification and quality control technology for the product. METHODS: We have developed a set of qualitative and quantitative methods based on gas chromatography/mass spectrometry (GC/MS) for the analysis of volatile components in Succus Bambusae oral liquid (SBOL). Combining GC/MS fingerprint analysis and related chemometrics algorithms, with similarity evaluation, Hotelling T(2) and distance to Model X (DModX) as criteria, the quality consistency of different batches was evaluated, and SBOL samples from different manufacturers were differentiated. RESULTS: Twenty-nine volatile components were preliminarily identified from 40 batches of SBOL samples from six manufacturers, and six Q-markers (Quality Markers) for the SBOLs were discussed and determined using GC/MS. The products from different manufacturers were distinguished using chemometrics. CONCLUSIONS: The results showed that the quality of the SBOL samples from different batches and different manufacturers fluctuated greatly, which suggested that research into the raw materials and manufacturing techniques should be strengthened to improve the quality of SBOL and ensure its quality consistency" |
| Keywords: | "Chemometrics/*methods China Drugs, Chinese Herbal/*chemistry Gas Chromatography-Mass Spectrometry/*methods Quality Control Volatile Organic Compounds/chemistry;" |
| Notes: | "MedlineFeng, Huimin Li, Shunan Hu, Yunfei Zeng, Xiyao Qiu, Ping Li, Yuanxiang Li, Wenlong Li, Zheng eng 2018ZX09201011/National S&T Major Project of China/ 82074276/the National Nature Science Foundation of China/ 20ZYJDJC00090/Tianjin Science and technology project/ Evaluation Study England 2021/09/18 Rapid Commun Mass Spectrom. 2021 Dec 30; 35(24):e9200. doi: 10.1002/rcm.9200" |
