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Food Funct

Title:		Prebiotic effect of fructans from Agave salmiana on probiotic lactic acid bacteria and in children as a supplement for malnutrition
Author(s):		Daniel MG; Mariano JG; Olivia GA; Cesar GH; Bertha JF; Rosa Isela OB; Maribel RA; Rogelio FR; Marco MM; Stefan R; Sylvia S; Horacio B; Fidel MG;
Address:		"Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Mexico. Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Manuel Nava 6, Zona Universitaria, San Luis Potosi, SLP 78210, Mexico. fidel@uaslp.mx. Facultad de Enfermeria y Nutricion, Universidad Autonoma de San Luis Potosi, Mexico. Instituto de Investigacion de Zonas Deserticas, Universidad Autonoma de San Luis Potosi, Mexico. Laboratorio Integral de Investigacion en Alimentos, Instituto Tecnologico de Tepic, Mexico. Coordinacion para la Innovacion y Aplicacion de la Ciencia y la Tecnologia, Universidad Autonoma de San Luis Potosi, Mexico. Institut fur Angewandte Mikrobiologie, Justus-Liebig-Universitat Giessen, Germany. Division of Infectious Diseases, Department of Medicine, University of British Columbia, Canada. Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, Mexico"
Journal Title:		Food Funct
Year:		2022
Volume:		20220404
Issue:		7
Page Number:		4184 - 4193
DOI:		10.1039/d1fo03852d
ISSN/ISBN:		2042-650X (Electronic) 2042-6496 (Linking)
Abstract:		"An imbalanced gut microbiota predisposes the development of nutritional disorders and chronic gastrointestinal diseases. Several studies have shown improvements on the host's health by enhancing the microbiota with prebiotics that stimulate probiotic microorganisms. This study describes the prebiotic effect of fructans from Agave salmiana consumed by children as a supplement for malnutrition. We report the extraction and degree of polymerization of fructans from A. salmiana, food safety and inflammatory analyses, and their effect in vitro on probiotic lactic acid bacteria (LAB). These fructans were included in the diet of 5-year-old normal-weight and malnourished children in double-blind, two-week interventions that compared the effects on their weight, bacterial count, and volatile organic compounds (VOCs). The extracted powdered fructans from A. salmiana had a composition comparable to inulin, were safe for human consumption, and stimulated the growth in vitro of three characteristic LAB. The children who consumed these fructans had a considerable weight gain, an increased number of LAB, and a decreased concentration of VOCs (indicative of less dysbiosis), demonstrating positive effects of this prebiotic on their microbiota, which were more significant in malnourished children. Fructans from A. salmiana induced in malnourished children significant weight gain and improved the functionality of their gut microbiota"
Keywords:		"*Agave Child, Preschool Double-Blind Method *Fructans/pharmacology Humans Inulin/pharmacology Lactobacillales *Malnutrition Prebiotics Probiotics;"
Notes:		"MedlineDaniel, Martinez-Gamino Mariano J, Garcia-Soto Olivia, Gonzalez-Acevedo Cesar, Godinez-Hernandez Bertha, Juarez-Flores Rosa Isela, Ortiz-Basurto Maribel, Rodriguez-Aguilar Rogelio, Flores-Ramirez Marco, Martinez-Martinez Stefan, Ratering Sylvia, Schnell Horacio, Bach Fidel, Martinez-Gutierrez eng England 2022/03/25 Food Funct. 2022 Apr 4; 13(7):4184-4193. doi: 10.1039/d1fo03852d"