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Cancer Epidemiol Biomarkers Prev

Title:		Impact of Cigarette Filter Ventilation on U.S. Smokers' Perceptions and Biomarkers of Exposure and Potential Harm
Author(s):		Carroll DM; Stepanov I; O'Connor R; Luo X; Cummings KM; Rees VW; Bickel WK; Berman ML; Ashley DL; Bansal-Travers M; Shields PG; Hatsukami DK;
Address:		"Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota. dcarroll@umn.edu. Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota. Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina. Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Fralin Biomedical Research Institute of Virginia Tech, Roanoke, Virginia. College of Public Health and Moritz College of Law, The Ohio State University, Columbus, Ohio. Department of Population Health Sciences, Georgia State University, Atlanta, Georgia. Comprehensive Cancer Center, The Ohio State University and James Cancer Hospital, Columbus, Ohio. Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota"
Journal Title:		Cancer Epidemiol Biomarkers Prev
Year:		2021
Volume:		20201022
Issue:		1
Page Number:		38 - 44
DOI:		10.1158/1055-9965.EPI-20-0852
ISSN/ISBN:		1538-7755 (Electronic) 1055-9965 (Print) 1055-9965 (Linking)
Abstract:		"BACKGROUND: Relationships between cigarette filter ventilation levels, biomarkers of exposure (BOE) and potential harm (BOPH), and harm perceptions were examined. METHODS: Filter ventilation levels in cigarette brands were merged with Wave 1 (2013-2014) Population Assessment of Tobacco Use and Health study. Data were restricted to smokers who reported a usual brand and not regular users of other tobacco products. BOEs included nicotine, tobacco-specific nitrosamines, volatile organic compounds (VOC), and polycyclic aromatic hydrocarbons. BOPHs measured inflammation and oxidative stress. Perceived harm was assessed as self-reported risk of one's usual brand compared with other brands. RESULTS: Filter ventilation ranged from 0.2% to 61.1% (n = 1,503). Adjusted relationships between filter ventilation and BOE or BOPH were nonsignificant except for VOC N-acetyl-S-(phenyl)-L-cysteine (PHMA) and high-sensitivity C-reactive protein (hsCRP). In pairwise comparisons, PHMA was higher in quartile (Q) 4 (4.23 vs. 3.36 pmol/mg; P = 0.0103) and Q3 (4.48 vs. 3.36 pmol/mg; P = 0.0038) versus Q1 of filter ventilation and hsCRP comparisons were nonsignificant. Adjusted odds of perceiving one's own brand as less harmful was 26.87 (95% confidence interval: 4.31-167.66), 12.55 (3.01-52.32), and 19.18 (3.87-95.02) times higher in the Q2, Q3, and Q4 of filter ventilation compared with Q1 (P = 0.0037). CONCLUSIONS: Filter ventilation was not associated with BOE or BOPH, yet smokers of higher ventilated cigarettes perceived their brand as less harmful than other brands compared with smokers of lower ventilated cigarettes. IMPACT: Research to understand the impact of this misperception is needed, and remedial strategies, potentially including a ban on filter ventilation, are recommended"
Keywords:		"Adult Biomarkers/blood/urine Cigarette Smoking/*adverse effects/psychology Female *Health Knowledge, Attitudes, Practice Humans Longitudinal Studies Male Perception Smokers/*psychology Tobacco Products/adverse effects/*classification United States;"
Notes:		"MedlineCarroll, Dana M Stepanov, Irina O'Connor, Richard Luo, Xianghua Cummings, K Michael Rees, Vaughan W Bickel, Warren K Berman, Micah L Ashley, David L Bansal-Travers, Maansi Shields, Peter G Hatsukami, Dorothy K eng P30 CA077598/CA/NCI NIH HHS/ UL1 TR002494/TR/NCATS NIH HHS/ K01 MD014795/MD/NIMHD NIH HHS/ K07 CA197221/CA/NCI NIH HHS/ T32 DA007097/DA/NIDA NIH HHS/ P01 CA217806/CA/NCI NIH HHS/ P30 CA016058/CA/NCI NIH HHS/ R01 CA179246/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural 2020/10/24 Cancer Epidemiol Biomarkers Prev. 2021 Jan; 30(1):38-44. doi: 10.1158/1055-9965.EPI-20-0852. Epub 2020 Oct 22"