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Sci Total Environ

Title:		"Environmentally relevant concentrations of geosmin affect the development, oxidative stress, apoptosis and endocrine disruption of embryo-larval zebrafish"
Author(s):		Zhou W; Wang J; Zhang J; Peng C; Li G; Li D;
Address:		"Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China; College of Chemistry, Biology and Environmental Engineering, Xiangnan University, Chenzhou 423000, PR China. Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China. Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China. Electronic address: lidh@ihb.ac.cn"
Journal Title:		Sci Total Environ
Year:		2020
Volume:		20200513
Issue:
Page Number:		139373 -
DOI:		10.1016/j.scitotenv.2020.139373
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"Geosmin (trans-1, 10-dimethyl-trans-9-decalol), a volatile organic compound, has been widely detected in aquatic ecosystems. However, the ecological effects of geosmin are not clear. Here, using zebrafish (Danio rerio) embryo as a model, we investigated biological activity effects of environmentally relevant concentrations (50, 500, 5000 ng/L) of geosmin on the developing zebrafish starting from 2 h post-fertilization (hpf) to 96 hpf. Results showed geosmin had no effect on hatchability, malformations and mortality. However, we observed that geosmin exposure significantly increased zebrafish body length in a concentration dependent manner. This effect was possibly due to up-regulation of expression of genes along the growth hormone/insulin-like growth factor (GH/IGF) axis and hypothalamic-pituitary-thyroid (HPT) axis. In addition, superoxide dismutase (SOD) activities and catalase (CAT) activities significantly increased at 96 hpf when the embryos were exposed to 500 and 5000 ng/L of geosmin. The malondialdehyde (MDA) contents and glutathione S-transferase (GST) activities decreased significantly after the exposure to 5000 ng/L geosmin. Simultaneously, exposure to geosmin resulted in significant increase in cell apoptosis, mainly in the heart area. The mRNA levels of the genes related to oxidative stress and apoptosis were also altered significantly after geosmin exposure. These findings indicated that geosmin can simultaneously induce multiple responses during zebrafish embryonic development, including oxidative stress, apoptosis, and endocrine disruption"
Keywords:		"Animals Apoptosis Ecosystem Embryo, Nonmammalian Larva Naphthols Oxidative Stress *Water Pollutants, Chemical *Zebrafish Geosmin Growth Zebrafish embryo;"
Notes:		"MedlineZhou, Weicheng Wang, Jinglong Zhang, Jinli Peng, Chengrong Li, Genbao Li, Dunhai eng Netherlands 2020/05/31 Sci Total Environ. 2020 Sep 15; 735:139373. doi: 10.1016/j.scitotenv.2020.139373. Epub 2020 May 13"