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Front Microbiol

Title:		Intestinal acetic acid regulates the synthesis of sex pheromones in captive giant pandas
Author(s):		Zhang MY; Zhang XH; Wang XY; Liu YL; An JH; Wang DH; Cai ZG; Hou R;
Address:		"Chengdu Research Base of Giant Panda Breeding, Chengdu, China. Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, China. Sichuan Academy of Giant Panda, Chengdu, China"
Journal Title:		Front Microbiol
Year:		2023
Volume:		20230825
Issue:
Page Number:		1234676 -
DOI:		10.3389/fmicb.2023.1234676
ISSN/ISBN:		1664-302X (Print) 1664-302X (Electronic) 1664-302X (Linking)
Abstract:		"As a typical solitary animal, adult giant pandas rely on chemical signals (sex pheromones) to transmit reproductive information during oestrous. Although researchers have confirmed that the gut microbiota is related to the emission and reception of sex pheromones, there is no clear correlation between the gut microbes and the synthesis of sex pheromone of giant pandas, that is, which gut microbes and microbial metabolites are participate in the synthesis of giant panda's sex pheromone. As a mirror of gut microbiota, fecal microbiota can reflect the composition of gut microbiota and its interaction with host to some extent. The purpose of this study is to explore how the gut microbes affect the synthesis of sex pheromones in captive giant pandas by combining analysis of the fecal microbiome and metabolomics. The results of correlation and microbial function analysis show that intestinal microorganisms such as Veillonellaceae and Lactobacillilaceae are associated with the synthesis of short chain fatty acid (acetic acid) and volatile ester metabolites, such as 1-butanol, 3-methyl, acetate, acetic acid, hexyl ester and 3-hexen-1-ol, acetate, (Z). In summary, based on this study, we believe that volatile metabolites such as fecal acetate participate in the process of mate preference of captive giant pandas and affect their expression of natural mating behavior. The possible mechanism is that the gut microbes can promote the synthesis of key chemical signaling substances in perianal glands through mediated intermediate fecal metabolites, thus affecting the normal information exchange between giant pandas individuals. The results of this study have greatly enriched our understanding of gut microbes regulating the synthesis of sex pheromones in giant pandas"
Keywords:		acetic acid captive giant pandas gut microbe mate preference sex pheromone;
Notes:		"PubMed-not-MEDLINEZhang, Ming-Yue Zhang, Xiao-Hui Wang, Xue-Ying Liu, Yu-Liang An, Jun-Hui Wang, Dong-Hui Cai, Zhi-Gang Hou, Rong eng Switzerland 2023/09/11 Front Microbiol. 2023 Aug 25; 14:1234676. doi: 10.3389/fmicb.2023.1234676. eCollection 2023"