| Title: | Effects of the maternal gut microbiome and gut-placental axis on melatonin efficacy in alleviating cadmium-induced fetal growth restriction |
| Author(s): | Zhang H; Liu X; Zheng Y; Zha X; Elsabagh M; Zhang Y; Ma Y; Loor JJ; Wang M; Wang H; |
| Address: | "Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR China. Department of Animal Production and Technology, Faculty of Agricultural Sciences and Technologies, Nigde Omer Halisdemir University, Nigde 51240, Turkey; Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt. Department of Animal Sciences, Division of Nutritional Sciences, University of Illinois, Urbana 61801, USA. Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR China. Electronic address: hrwang@yzu.edu.cn" |
| DOI: | 10.1016/j.ecoenv.2022.113550 |
| ISSN/ISBN: | 1090-2414 (Electronic) 0147-6513 (Linking) |
| Abstract: | "Cadmium (Cd) is a major environmental stressor that induces fetal growth restriction (FGR). Also, changes in gut microbiome diversity-which can be modulated positively by melatonin (Mel) have implications on fetal development and placental functions. Therefore, this study aimed to explore whether the role of Mel in counteracting the Cd-induced FGR by regulating placental barrier injury, endoplasmic reticulum stress (ERS) and mitophagy in pregnant mice is mediated-in part- via the gut microbiota modulations. Pregnant mice were intraperitoneally injected with CdCl(2) (5 mg/kg) and Mel (5 mg/kg) once daily, respectively, at the same time from gestational day (GD) 8 to GD18, and then the maternal colon and placental tissues were collected for detection. To investigate the inner relationship between intestinal flora and the protection of Mel on FGR caused by Cd, gut microbiota transplantation (GMT) was carried out from GD0 to GD18 after the removal of intestinal microbiota by antibiotics. Results indicated that Mel relieved barrier injury, ERS and mitophagy in the placenta, and reversed the maternal gut microbiota dysbiosis. The GMT approach suggested a role of intestinal microbiota in placental barrier injury, ERS and mitophagy induced by Cd. Overall, the results highlighted that the intestinal microbiota and gut-placental axis play a central role in the protective effect of Mel against Cd-induced FGR" |
| Keywords: | Animals Cadmium/toxicity Female Fetal Growth Retardation/chemically induced *Gastrointestinal Microbiome Humans *Melatonin/pharmacology/therapeutic use Mice Placenta Pregnancy Cadmium Fetal growth restriction Gut microbiota Gut-placenta axis Melatonin; |
| Notes: | "MedlineZhang, Hao Liu, Xiaoyun Zheng, Yi Zha, Xia Elsabagh, Mabrouk Zhang, Ying Ma, Yi Loor, Juan J Wang, Mengzhi Wang, Hongrong eng Netherlands 2022/04/30 Ecotoxicol Environ Saf. 2022 Jun 1; 237:113550. doi: 10.1016/j.ecoenv.2022.113550. Epub 2022 Apr 26" |
