| Title: | Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation |
| Author(s): | Wang C; Dong R; Wang X; Lian A; Chi C; Ke C; Guo L; Liu S; Zhao W; Xu G; Li E; |
| Address: | "Department of Anesthesiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Biostatistics, School of Public Health, Harbin Medical University, Harbin, China. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "In this study, single-lung ventilation was used to detect differences in the volatile organic compound (VOCs) profiles between lung tissues in healthy and affected lungs. In addition, changes that occurred after lung cancer resection in both the VOCs profiles of exhaled breath from ipsilateral and contralateral lungs and the VOCs profiles of exhaled breath and blood sample headspaces were also determined. Eighteen patients with non-small cell carcinoma were enrolled. Alveolar breath samples were taken separately from healthy and diseased lungs before and after the tumor resection. Solid phase microextraction-gas chromatography/mass spectrometry was used to assess the exhaled VOCs of the study participants. The VOCs exhibited significant differences between the contralateral and ipsilateral lungs before surgery, the contralateral and ipsilateral lungs after surgery, the ipsilateral lungs before and after surgery, and the blood samples from before and after surgery; 12, 19, 12 and 5 characteristic metabolites played decisive roles in sample classification, respectively. 2,2-Dimethyldecane, tetradecane, 2,2,4,6,6-pentamethylheptane, 2,3,4-trimethyldecane, nonane, 3,4,5,6-tetramethyloctane, and hexadecane may be generated from lipid peroxidation during surgery. Caprolactam and propanoic acid may be more promising exhaled breath biomarkers for lung cancer" |
| Keywords: | Aged Biomarkers/blood/metabolism *Exhalation Female Gas Chromatography-Mass Spectrometry Humans Lung Neoplasms/blood/diagnosis/*metabolism Male Middle Aged Neoplasm Metastasis Neoplasm Staging *One-Lung Ventilation Volatile Organic Compounds/*metabolism; |
| Notes: | "MedlineWang, Changsong Dong, Ran Wang, Xiaoyang Lian, Ailing Chi, Chunjie Ke, Chaofu Guo, Lei Liu, Shanshan Zhao, Wei Xu, Guowang Li, Enyou eng Research Support, Non-U.S. Gov't England 2014/12/09 Sci Rep. 2014 Dec 8; 4:7312. doi: 10.1038/srep07312" |
