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Reprod Toxicol

Title:		Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes: Potential risks to meiotic maturation
Author(s):		Udagawa O; Furuyama A; Imai K; Fujitani Y; Hirano S;
Address:		"Center for Health & Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. Electronic address: udagawa.osamu@nies.go.jp. Center for Health & Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan"
Journal Title:		Reprod Toxicol
Year:		2018
Volume:		20171120
Issue:
Page Number:		56 - 64
DOI:		10.1016/j.reprotox.2017.11.006
ISSN/ISBN:		1873-1708 (Electronic) 0890-6238 (Linking)
Abstract:		"Particulate air pollution (PM 2.5) is a worldwide concern. Growing epidemiological evidence has shown pathophysiological effects of PM 2.5, not only on cardiovascular system but also on reproductive performance. The composition and physicochemical properties of PM 2.5 vary depending on the emission sources, climate conditions, and complex chemical reactions in the air. These factors make it difficult to understand the cause and mechanistic details of the adverse health effects of PM 2.5. Here, we show potential impacts of PM 2.5 on oocyte maturation in mice by utilizing diesel exhaust-derived secondary organic aerosol (SOA), a major component of urban PM 2.5. We found that the SOA destabilized microtubules of mouse oocytes and p-benzoquinone is one of the candidates for the microtubule-destabilizing compounds. We propose that some biologically reactive components of PM 2.5 should be prioritized for the regulation of atmospheric quality"
Keywords:		"Aerosols Air Pollutants/chemistry/*toxicity Animals Benzoquinones/chemistry/toxicity Female Inhalation Exposure Meiosis/*drug effects Mice, Inbred C57BL Microtubules/drug effects Mitochondria/drug effects Oocytes/cytology/*drug effects Particle Size Parti;"
Notes:		"MedlineUdagawa, Osamu Furuyama, Akiko Imai, Koji Fujitani, Yuji Hirano, Seishiro eng Research Support, Non-U.S. Gov't 2017/11/22 Reprod Toxicol. 2018 Jan; 75:56-64. doi: 10.1016/j.reprotox.2017.11.006. Epub 2017 Nov 20"