| Title: | Acute and chronic pain management in patients with sickle cell disease in the modern era: a comprehensive review |
| Address: | "Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, 161 Fort Washington, New York, NY 10032, USA. Electronic address: St3406@cumc.columbia.edu. Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, 161 Fort Washington, New York, NY 10032, USA. Electronic address: lnv2109@cumc.columbia.edu" |
| DOI: | 10.1016/j.transci.2022.103533 |
| ISSN/ISBN: | 1473-0502 (Print) 1473-0502 (Linking) |
| Abstract: | "Sickle cell disease (SCD) is the most common inherited red blood cell (RBC) disorder worldwide, resulting in chronic hemolytic anemia, vaso-occlusion, tissue hypoxia, and ultimately end organ damage. The hallmark of the disease is manifested by vaso-occlusive crisis (VOC) resulting in acute on chronic pain, and the most common cause for presentation to the emergency department and hospital admission. The management of pain for patients with SCD in the U.S. has historically been socially and politically complex with most patients experiencing pain on a daily basis but not seeking immediate medical attention. The pathophysiology of acute and chronic pain in SCD is multifactorial and complex. Here, we describe factors contributing to acute and chronic pain in SCD and management strategies" |
| Keywords: | "Humans Pain Management/methods *Chronic Pain/etiology/therapy *Volatile Organic Compounds *Anemia, Sickle Cell/complications/therapy *Vascular Diseases Acute pain Chronic pain Neuropathic pain Sickle cell disease Vaso-occlusive crisis;" |
| Notes: | "MedlineTolu, Seda S Van Doren, Layla eng Review England 2022/09/05 Transfus Apher Sci. 2022 Oct; 61(5):103533. doi: 10.1016/j.transci.2022.103533. Epub 2022 Aug 29" |
