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Chem Commun (Camb)

Title:		Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2
Author(s):		Tanaka S; Yamamura T; Nakane S; Kitamura M;
Address:		"Graduate School of Pharmaceutical Sciences, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8601, Japan. kitamura@os.rcms.nagoya-u.ac.jp"
Journal Title:		Chem Commun (Camb)
Year:		2015
Volume:		51
Issue:		66
Page Number:		13110 - 13112
DOI:		10.1039/c5cc04594k
ISSN/ISBN:		1364-548X (Electronic) 1359-7345 (Linking)
Abstract:		"A versatile method has been found to catalyze the dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using Pd/C, volatile iPr3SiH and CO2 gas without the liberation of any salts. A simple filtration/evaporation process facilitates the easy isolation of the product, thereby enhancing the utility of Tsoc as an amine-protecting group in organic synthesis"
Keywords:		Amines/*chemistry Carbon Dioxide/*chemistry Catalysis Hydrogenation Trimethylsilyl Compounds/*chemistry;
Notes:		"MedlineTanaka, S Yamamura, T Nakane, S Kitamura, M eng Research Support, Non-U.S. Gov't England 2015/07/18 Chem Commun (Camb). 2015 Aug 25; 51(66):13110-2. doi: 10.1039/c5cc04594k"