| Title: | Mammalian pheromones: emerging properties and mechanisms of detection |
| Address: | "Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: Stowers@scripps.edu. Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: Kuoth@scripps.edu" |
| DOI: | 10.1016/j.conb.2015.02.005 |
| ISSN/ISBN: | 1873-6882 (Electronic) 0959-4388 (Print) 0959-4388 (Linking) |
| Abstract: | "The concept of mammalian pheromones was established decades before the discovery of any bioactive ligands. Therefore, their molecular identity, native sources, and the meaning of their detection has been largely speculative. There has been recent success in identifying a variety of candidate mouse pheromones and other specialized odors. These discoveries reveal that mammalian pheromones come in a variety of ligand types and they are detected by sensory neurons that are pre-set to promote an array of social and survival behaviors. Importantly, recent findings show that they activate molecularly diverse sensory neurons that differ from canonical odorant detectors. These novel sensory neurons hold future promise to unlock the mystery of how their detection is hardwired to generate behavior" |
| Keywords: | Animals Mammals Mice Olfactory Mucosa/*cytology Olfactory Receptor Neurons/*physiology Pheromones/*physiology Sensory Thresholds/*physiology Vomeronasal Organ/*cytology;neuroscience; |
| Notes: | "MedlineStowers, Lisa Kuo, Tsung-Han eng R01 DC006885/DC/NIDCD NIH HHS/ R01 DC009413/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England 2015/03/10 Curr Opin Neurobiol. 2015 Oct; 34:103-9. doi: 10.1016/j.conb.2015.02.005. Epub 2015 Mar 6" |
