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Chem Res Toxicol

Title:		Integrative Analysis of lncRNA-mRNA Coexpression in Human Lung Epithelial Cells Exposed to Dimethyl Selenide-Derived Secondary Organic Aerosols
Author(s):		Sabbir Ahmed CM; Paul BC; Cui Y; Frie AL; Burr A; Kamath R; Chen JY; Nordgren TM; Bahreini R; Lin YH;
Address:		"Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, United States. Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, United States. Harvard Medical School, Boston, Massachusetts 02115, United States. Department of Environmental Sciences, University of California, Riverside, California 92521, United States. Division of Biomedical Sciences, University of California, Riverside, California 92521, United States"
Journal Title:		Chem Res Toxicol
Year:		2021
Volume:		20210303
Issue:		3
Page Number:		892 - 900
DOI:		10.1021/acs.chemrestox.0c00516
ISSN/ISBN:		1520-5010 (Electronic) 0893-228X (Linking)
Abstract:		"Dimethyl selenide (DMSe) is one of the major volatile organoselenium compounds released into the atmosphere through plant metabolism and microbial methylation. DMSe has been recently revealed as a precursor of secondary organic aerosol (SOA), and its resultant SOA possesses strong oxidizing capability toward thiol groups that can perturb several major biological pathways in human airway epithelial cells and is linked to genotoxicity, DNA damage, and p53-mediated stress responses. Mounting evidence has suggested that long noncoding RNAs (lncRNAs) are involved in stress responses to internal and environmental stimuli. However, the underlying molecular interactions remain to be elucidated. In this study, we performed integrative analyses of lncRNA-mRNA coexpression in the transformed human bronchial epithelial BEAS-2B cell line exposed to DMSe-derived SOA. We identified a total of 971 differentially expressed lncRNAs in BEAS-2B cells exposed to SOA derived from O(3) and OH oxidation of DMSe. Gene ontology (GO) network analysis of cis-targeted genes showed significant enrichment of DNA damage, apoptosis, and p53-mediated stress response pathways. trans-Acting lncRNAs, including PINCR, PICART1, DLGAP1-AS2, and LINC01629, known to be associated with human carcinogenesis, also showed altered expression in cell treated with DMSe-SOA. Overall, this study highlights the regulatory role of lncRNAs in altered gene expression induced by DMSe-SOA exposure"
Keywords:		"Aerosols/pharmacology Cells, Cultured Epithelial Cells/*drug effects/metabolism Humans Lung/*drug effects/metabolism Organoselenium Compounds/*pharmacology RNA, Long Noncoding/*genetics RNA, Messenger/*genetics RNA-Seq;"
Notes:		"MedlineSabbir Ahmed, C M Paul, Biplab Chandra Cui, Yumeng Frie, Alexander L Burr, Abigail Kamath, Rohan Chen, Jin Y Nordgren, Tara M Bahreini, Roya Lin, Ying-Hsuan eng S10 OD016290/OD/NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. 2021/03/04 Chem Res Toxicol. 2021 Mar 15; 34(3):892-900. doi: 10.1021/acs.chemrestox.0c00516. Epub 2021 Mar 3"