| Title: | Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective |
| Author(s): | Ren W; Wang K; Yin J; Chen S; Liu G; Tan B; Wu G; Bazer FW; Peng Y; Yin Y; |
| Address: | "Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China; University of the Chinese Academy of Sciences, Beijing, China. Institute of Apicultural Research (IAR), Chinese Academy of Agricultural Sciences (CAAS) , Beijing , China. Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences , Changsha , China. Department of Animal Science, Texas A&M University , College Station, TX , USA. Chongqing Key Laboratory of Forage & Herbivore, College of Animal Science and Technology, Southwest University , Chongqing , China. Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China; College of Animal Science, South China Agricultural University, Guangzhou, China" |
| ISSN/ISBN: | 1664-3224 (Print) 1664-3224 (Electronic) 1664-3224 (Linking) |
| Abstract: | "Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA. Altogether, the glutamine-intestinal SIgA axis has broad therapeutic implications for intestinal SIgA-associated diseases, such as celiac disease, allergies, and inflammatory bowel disease" |
| Keywords: | T cells glutamine intestinal microbiota secretory IgA; |
| Notes: | "PubMed-not-MEDLINERen, Wenkai Wang, Kai Yin, Jie Chen, Shuai Liu, Gang Tan, Bie Wu, Guoyao Bazer, Fuller W Peng, Yuanyi Yin, Yulong eng Review Switzerland 2016/12/10 Front Immunol. 2016 Nov 24; 7:503. doi: 10.3389/fimmu.2016.00503. eCollection 2016" |
