| Title: | "Intracellular signal transduction of PBAN action in lepidopteran insects: inhibition of sex pheromone production by compactin, an HMG CoA reductase inhibitor" |
| Author(s): | Ozawa R; Matsumoto S; Kim GH; Uchiumi K; Kurihara M; Shono T; Mitsui T; |
| Address: | "Institute of Physical and Chemical Research (RIKEN), Saitama, Japan" |
| DOI: | 10.1016/0167-0115(95)00045-D |
| ISSN/ISBN: | 0167-0115 (Print) 0167-0115 (Linking) |
| Abstract: | "Pheromone biosynthesis activating neuropeptide (PBAN) regulates sex pheromone production in the pheromone glands of many species of female moths. In order to probe the biochemical steps as well as underlying mechanisms regulated by PBAN, we have tested the effect of chemicals on sex pheromone production by using an in vitro assay. Among the chemicals we tested here, compactin, a specific 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor, clearly inhibited the pheromone biosynthesis in the silkworm, Bombyx mori, and the common cutworm, Spodoptera litura. Since the activation of HMG CoA reductase occurs by dephosphorylation mediated by a specific phosphatase and the biochemical step regulated by PBAN in bombykol biosynthesis is similar to the one catalyzed by HMG-CoA reductase in cholesterol biosynthesis, the present results support the idea that phosphoprotein phosphatase has a significant role to regulate bombykol production in the intracellular transduction of PBAN action in B. mori" |
| Keywords: | Amino Acid Sequence Animals Bombyx/*drug effects/enzymology Enzyme Inhibitors/*pharmacology Female *Hydroxymethylglutaryl-CoA Reductase Inhibitors Lovastatin/*analogs & derivatives/pharmacology Molecular Sequence Data Neuropeptides/*physiology Sex Attract; |
| Notes: | "MedlineOzawa, R Matsumoto, S Kim, G H Uchiumi, K Kurihara, M Shono, T Mitsui, T eng Research Support, Non-U.S. Gov't Netherlands 1995/06/27 Regul Pept. 1995 Jun 27; 57(3):319-27. doi: 10.1016/0167-0115(95)00045-D" |
