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J Appl Anim Welf Sci

Title:		Hormonal-Induced Cervical Relaxation During Diestrus in Ewes: Cervical Transposing Feasibility and Use of hCG for Rescuing Disrupted Luteal Function
Author(s):		Oliveira MEF; Arrais AM; Vergani GB; Novita Esteves S; Schinaider Do Amaral Pereira V; Garcia AR; Bastos R; Roberto Bourg Melo M; Rios Coelho Alves B; Ferreira Fonseca J;
Address:		"Faculdade de Ciencias Agrarias e Veterinarias, Universidade Estadual Paulista (UNESP), Jaboticabal, Brazil. Embrapa Caprinos e Ovinos (CNPC), Coronel Pacheco, Brazil. Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropedica, Brazil. Embrapa Pecuaria Sudeste (CPPSE), Sao Carlos, Brazil. Universidade Estadual do Norte Fluminense Darcy Ribeiro, Brazil. Universidade Federal Fluminense, Niteroi, Brazil"
Journal Title:		J Appl Anim Welf Sci
Year:		2022
Volume:		20221107
Issue:
Page Number:		1 - 17
DOI:		10.1080/10888705.2022.2141576
ISSN/ISBN:		1532-7604 (Electronic) 1088-8705 (Linking)
Abstract:		"Cervical relaxation (CR) was performed in ewes during diestrus, to prospect a feasible protocol for non-surgical embryo transfer (NSET). In Trial 1, naturally mated ewes (n=13) received CR protocols with estradiol benzoate (EB, 1 mg on D6) and oxytocin (OT, 50 IU on D7) only (G-EB+OT) or associated with human chorionic gonadotropin (hCG, 300 IU on D7, G-EB+OT+hCG) and were compared to non-hormonally treated (G-control) ewes. Estradiol concentration increased (P<0.05) from D6 to D7 in G-EB+OT and G-EB+OT+hCG, then decreased (P<0.05) on D8. The G-EB+OT had reduced (P<0.05) progesterone on D8, and 0% (0/5) pregnancy, while G-control had 100% (3/3) conception rate. The treatment with hCG mitigated the progesterone drop on D8 and resulted in 50% (2/4) conception rate. In Trial 2, cervical transposing success after treatment with EB, OT, and hCG on D6 and D7 was assessed in nulliparous (n=25) and multiparous (n=30) ewes. The EB+OT+hCG protocol allowed efficient cervical transposition (~78% of cervical transposition success into ~5 min) in nulliparous and multiparous females and did not alter total and blood perfusion areas of corpora lutea (CL). The use of EB+OT+hCG was efficient to ensure effective cervical transposing in nulliparous and multiparous ewes, with no apparent deleterious effect on CL function, and may contribute to animal welfare, allowing a less invasive NSET procedure"
Keywords:		Embryo transfer animal welfare non-surgical pharmacological transcervical;
Notes:		"PublisherOliveira, Maria Emilia Franco Arrais, Aline Matos Vergani, Gabriel Brun Novita Esteves, Sergio Schinaider Do Amaral Pereira, Veronica Garcia, Alexandre Rossetto Bastos, Rosemary Roberto Bourg Melo, Marco Rios Coelho Alves, Bruna Ferreira Fonseca, Jeferson eng England 2022/11/08 J Appl Anim Welf Sci. 2022 Nov 7:1-17. doi: 10.1080/10888705.2022.2141576"