| Title: | The mating-type region of Schizosaccharomyces pombe contains an essential gene encoding a protein homologous to human modulators of HIV transactivation |
| Author(s): | Michael H; Schmidt H; Fleck O; Gutz H; Liedtke C; Lorentz A; Ostermann K; |
| Address: | "Institut fur Genetik, Technische Universitat Braunschweig, Germany" |
| DOI: | 10.1016/0378-1119(94)90006-x |
| ISSN/ISBN: | 0378-1119 (Print) 0378-1119 (Linking) |
| Abstract: | "In Schizosaccharomyces pombe, an intrachromosomal crossover between the mating type (MT) expression locus and one of the silent donor cassettes is lethal due to the loss of the intervening L region. The region contains one essential gene, let1. This gene was cloned and sequenced. The deduced amino acid (aa) sequence of let1 shows extensive homologies with SUG1 from Saccharomyces cerevisiae. Significant homologies were also found with the human HIV transactivation modulators, MSS1 and TBP-1, as well as with subunit 4 of the mammalian 26 S protease. The data indicate that let1 is a member of a recently defined multigene family of ATPases" |
| Keywords: | "Adenosine Triphosphatases/classification/*genetics Amino Acid Sequence Base Sequence Cloning, Molecular Fungal Proteins/*genetics Genes, Fungal/*genetics Genes, Lethal/*genetics *Genes, Mating Type, Fungal HIV/genetics Humans Mating Factor Molecular Seque;" |
| Notes: | "MedlineMichael, H Schmidt, H Fleck, O Gutz, H Liedtke, C Lorentz, A Ostermann, K eng Comparative Study Research Support, Non-U.S. Gov't Netherlands 1994/08/05 Gene. 1994 Aug 5; 145(2):205-10. doi: 10.1016/0378-1119(94)90006-x" |
