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Plants (Basel)

Title:		Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling
Author(s):		Lazovic M; Cvijetic I; Jankov M; Milojkovic-Opsenica D; Trifkovic J; Ristivojevic P;
Address:		"Innovation Centre of Faculty of Chemistry Ltd., Studentski Trg 12-16, 11158 Belgrade, Serbia. University of Belgrade-Faculty of Chemistry, Studentski Trg 12-16, 11158 Belgrade, Serbia"
Journal Title:		Plants (Basel)
Year:		2022
Volume:		20220908
Issue:		18
Page Number:		-
DOI:		10.3390/plants11182346
ISSN/ISBN:		2223-7747 (Print) 2223-7747 (Electronic) 2223-7747 (Linking)
Abstract:		"To replace common organic solvents that present inherent toxicity and have high volatility and to improve the extraction efficiency, a range of natural deep eutectic solvents (NADESs) were evaluated for the extraction of phenolic compounds from Agrimonia eupatoria. Screening of NADES efficiency was carried out based on the total phenolic and flavonoid content and radical-scavenging activity, determined by spectrophotometry, as well as phenolic compounds quantified, obtained using ultra-high-performance liquid chromatography with a diode array detector and a triple-quadrupole mass spectrometer. Increased extraction efficiency when compared with organic solvent was achieved using NADES mixtures choline chloride (ChCl):urea 1:2 and choline chloride:glycerol 1:1. Flavonol glycosides were the most abundant compounds in all extracts. The COSMO-RS model provided insights into the most important intermolecular interactions that drive the extraction process. Moreover, it could explain the extraction efficiency of flavonol glycosides using ChCl:glycerol NADES. The current article offers experimental evidence and mechanistic insights for the selection of optimal NADES to extract bioactive components from Agrimonia eupatoria"
Keywords:		Uhplc-dad-ms/ms conductor-like screening model for realistic solvation flavonol glycosides heating extraction method natural deep eutectic solvents;
Notes:		"PubMed-not-MEDLINELazovic, Mila Cvijetic, Ilija Jankov, Milica Milojkovic-Opsenica, Dusanka Trifkovic, Jelena Ristivojevic, Petar eng 451-03-68/2022-14/200168 and 451-03-68/2022-14/200288/Ministry of Education, Science and Technological Development of Republic of Serbia/ Switzerland 2022/09/24 Plants (Basel). 2022 Sep 8; 11(18):2346. doi: 10.3390/plants11182346"