| Title: | Acute health effects from exposure to indoor ultrafine particles-A randomized controlled crossover study among young mild asthmatics |
| Author(s): | Laursen KR; Rasmussen BB; Rosati B; Gutzke VH; Ostergaard K; Ravn P; Kjaergaard SK; Bilde M; Glasius M; Sigsgaard T; |
| Address: | "Environment, Work and Health, Department of Public Health, Aarhus University, Aarhus, Denmark. Department of Chemistry, Aarhus University, Aarhus, Denmark. Faculty of Physics, University of Vienna, Vienna, Austria" |
| ISSN/ISBN: | 1600-0668 (Electronic) 0905-6947 (Linking) |
| Abstract: | "Particulate matter is linked to adverse health effects, however, little is known about health effects of particles emitted from typical indoor sources. We examined acute health effects of short-term exposure to emissions from cooking and candles among asthmatics. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions lasting 5 h: (a) air mixed with emissions from cooking (fine particle mass concentration): (PM(2.5) : 96.1 mug/m(3) ), (b) air mixed with emissions from candles (PM(2.5) : 89.8 mug/m(3) ), and c) clean filtered air (PM(2.5) : 5.8 mug/m(3) ). Health effects (spirometry, fractional exhaled Nitric Oxide [FeNO], nasal volume and self-reported symptoms) were evaluated before exposure start, then 5 and 24 h after. During exposures volatile organic compounds (VOCs), particle size distributions, number concentrations and optical properties were measured. Generally, no statistically significant changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. The results indicate that emissions from cooking and candles exert mild inflammation in asthmatic males and decrease comfort among asthmatic males and females" |
| Keywords: | "*Air Pollutants/analysis *Air Pollution, Indoor/adverse effects/analysis Cooking Cross-Over Studies Environmental Monitoring Female Humans Male Particle Size Particulate Matter/adverse effects/analysis candles human exposure indoor air inflammation partic;" |
| Notes: | "MedlineLaursen, Karin Rosenkilde Rasmussen, Berit Brondum Rosati, Bernadette Gutzke, Vibeke Heitmann Ostergaard, Kirsten Ravn, Peter Kjaergaard, Soren Kenneth Bilde, Merete Glasius, Marianne Sigsgaard, Torben eng Randomized Controlled Trial Research Support, Non-U.S. Gov't England 2021/07/09 Indoor Air. 2021 Nov; 31(6):1993-2007. doi: 10.1111/ina.12902. Epub 2021 Jul 7" |
