| Title: | [Attractive and immunosuppressive properties of volatile secretions induced in mice separately and combine influence of ionizing radiation and cyclophosphamide] |
| ISSN/ISBN: | 0869-8031 (Print) 0869-8031 (Linking) |
| Abstract: | "We have studied the properties of volatile secretions induced in laboratory mice, separately or combined influence of ionizing radiation and cyclophosphamide. The reaction of preference-avoidance response in the T-maze revealed that the urine samples of mice in the early period after exposure to ionizing radiation in doses of 2 and 4 Gy contain attractive for intact animals volatile components. While the introduction of cyclophosphamide in doses of 20 or 35 mg/g provokes the secretion of volatile components of aversive, repealing properties towards of intact individuals. Combined exposure to these factors leads to a reciprocal compensation of the impact of volatile secretions in the preference-avoidance response of intact mice. The examined effects depend to some extent on the dose of radiation and cyclophosphamide. Induced both by separate and associated exposure to radiation and cyclophosphamide volatile allocation have depressing effect of the humoral immune response, regardless of whether they are attractive or aversive properties. We are discussing their role in the mechanisms of chemosignaling" |
| Keywords: | "Animals Avoidance Learning/drug effects Cyclophosphamide/*toxicity Immune Tolerance/*drug effects Male Maze Learning/drug effects Mice Mice, Inbred CBA Radiation, Ionizing Sex Attractants/*metabolism/*pharmacology/urine Volatilization *Whole-Body Irradiat;" |
| Notes: | "MedlineAbramova, M R Surinov, B P rus Research Support, Non-U.S. Gov't Russia (Federation) 2010/03/20 Radiats Biol Radioecol. 2010 Jan-Feb; 50(1):74-80" |
