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SAR QSAR Environ Res

Title:		An integrated QSPR-PBPK modelling approach for in vitro-in vivo extrapolation of pharmacokinetics in rats
Author(s):		Kamgang E; Peyret T; Krishnan K;
Address:		"Groupe de recherche interdisciplinaire en sante, Faculte de medecine, Universite de Montreal, Montreal, QC, Canada"
Journal Title:		SAR QSAR Environ Res
Year:		2008
Volume:		19
Issue:		7-Aug
Page Number:		669 - 680
DOI:		10.1080/10629360802547313
ISSN/ISBN:		1029-046X (Electronic) 1026-776X (Linking)
Abstract:		"In vitro data on metabolism and partitioning may be integrated within physiologically-based pharmacokinetic (PBPK) models to provide simulations of the kinetics and bioaccumulation of chemicals in intact organisms. Quantitative structure-property relationship (QSPR) modelling of available in vitro data may be performed to predict metabolism rates and partition coefficients (PCs) for developing in vivo PBPK models. The objective of the present study was to develop an integrated QSPR-PBPK modelling approach for the conduct of in vitro to in vivo extrapolation. For this purpose, data on rat blood:air (P(b)) and fat:air (P(f)) PCs, as well as intrinsic metabolic clearance (CL(int)) obtained using rat liver slices for some C(5)-C(10) volatile organic compounds (VOCs) were compiled from the literature. Multilinear additive QSPR models for P(f), P(b) and CL(int) were developed based on the number and nature of molecular fragments in these VOCs (CH(3), CH(2), CH, C, C=C, H, benzene ring and H in benzene ring structure). The mean estimated/experimental (est/exp) ratios (+/-SD; range) were 1.0 (+/-0.04; 0.93 - 1.06) for log P(f), 1.08 (+/-0.26; 0.70 - 1.62) for log P(b), and 1.07 (+/- 0.21; 0.80 - 1.44) for CL(int). By accounting for the difference in the content of neutral lipids in fat and other tissues, the liver : air and muscle : air PCs of the compounds investigated in this study, with the excerption of n-decane, were adequately predicted from P(f). Integrating the QSPRs for P(f), P(b) and CL(int) within a rat PBPK model, simulations of inhalation pharmacokinetics of several VOCs were generated on the basis of molecular structure, for a given exposure scenario. The integrated QSPR-PBPK model developed in this study is a potentially useful tool for predicting in vivo kinetics and bioaccumulation of chemicals in rats under poor data situations"
Keywords:		"Animals Liver/metabolism Metabolic Clearance Rate Models, Theoretical Rats Tissue Distribution Toxicology/*methods Volatile Organic Compounds/metabolism/*pharmacokinetics;"
Notes:		"MedlineKamgang, E Peyret, T Krishnan, K eng Meta-Analysis Research Support, Non-U.S. Gov't England 2008/12/09 SAR QSAR Environ Res. 2008; 19(7-8):669-80. doi: 10.1080/10629360802547313"