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Pain

Title:		Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons
Author(s):		Inoue T; Bryant BP;
Address:		"Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA"
Journal Title:		Pain
Year:		2005
Volume:		117
Issue:		1-Feb
Page Number:		193 - 203
DOI:		10.1016/j.pain.2005.06.012
ISSN/ISBN:		0304-3959 (Print) 0304-3959 (Linking)
Abstract:		"Many volatile organic compounds (VOCs) are significant environmental irritants that stimulate somatosensory nerve endings to produce pain and irritation. We measured intracellular calcium in cultured trigeminal ganglion neurons to characterize the cellular mechanisms and chemical structural determinants underlying sensitivity to VOCs. Trigeminal neurons responded to homologous series of alcohols (C4-C7) as well as saturated and unsaturated aldehydes in a concentration dependent manner. Ranked in terms of threshold to recruit neurons by compounds of the same carbon chain length, enaldehyde
Keywords:		"Aldehydes/pharmacology Animals Animals, Newborn Calcium/*metabolism Capsaicin/analogs & derivatives/pharmacology Central Nervous System Depressants/pharmacology Diagnostic Imaging/methods Dose-Response Relationship, Drug Drug Interactions Ethanol/pharmaco;"
Notes:		"MedlineInoue, Takashi Bryant, Bruce P eng Comparative Study Research Support, Non-U.S. Gov't 2005/07/27 Pain. 2005 Sep; 117(1-2):193-203. doi: 10.1016/j.pain.2005.06.012"