« Previous AbstractGene Regulation and Species-Specific Evolution of Free Flight Odor Tracking in Drosophila    Next AbstractThe neonicotinoid insecticide thiamethoxam enhances expression of stress-response genes in Zea mays in an environmentally specific pattern »

Dermatology

Title:		Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms
Author(s):		Houschyar KS; Borrelli MR; Tapking C; Popp D; Puladi B; Ooms M; Chelliah MP; Rein S; Pforringer D; Thor D; Reumuth G; Wallner C; Branski LK; Siemers F; Grieb G; Lehnhardt M; Yazdi AS; Maan ZN; Duscher D;
Address:		"Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, USA. Department of Surgery, Shriners Hospitals for Children-Galveston, University of Texas Medical Branch, Galveston, Texas, USA. Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Heidelberg, Germany. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria. Department of Oral and Maxillofacial Surgery, University Hospital RWTH, Aachen, Germany. Department of Plastic and Hand Surgery, Burn Center, Clinic St. Georg, Leipzig, Germany. Clinic and Policlinic of Trauma Surgery, Klinikum Rechts der Isar, Technische Universitat Munchen, Munich, Germany. College of Pharmacy, University of Florida Gainesville, Gainesville, Florida, USA. Department of Plastic and Hand Surgery, Burn Unit, Trauma Center Bergmannstrost Halle, Halle, Germany. Department of Plastic Surgery and Hand Surgery, Gemeinschaftskrankenhaus Havelhoehe, Teaching Hospital of the Charite Berlin, Berlin, Germany. Department of Dermatology and Allergology, University Hospital Aachen, Aachen, Germany. Department of Plastic Surgery and Hand Surgery, Technical University Munich, Munich, Germany, dominik.duscher@mri.tum.de"
Journal Title:		Dermatology
Year:		2020
Volume:		20200312
Issue:		4
Page Number:		271 - 280
DOI:		10.1159/000506155
ISSN/ISBN:		1421-9832 (Electronic) 1018-8665 (Linking)
Abstract:		"Hair is a defining feature of mammals and has critical functions, including protection, production of sebum, apocrine sweat and pheromones, social and sexual interactions, thermoregulation, and provision of stem cells for skin homeostasis, regeneration, and repair. The hair follicle (HF) is considered a 'mini-organ,' consisting of intricate and well-organized structures which originate from HF stem and progenitor cells. Dermal papilla cells are the main components of the mesenchymal compartments in the hair bulb and are instrumental in generating signals to regulate the behavior of neighboring epithelial cells during the hair cycle. Mesenchymal-epithelial interactions within the dermal papilla niche drive HF embryonic development as well as the postnatal hair growth and regeneration cycle. This review summarizes the current understanding of HF development, repair, and regeneration, with special focus on cell signaling pathways governing these processes. In particular, we discuss emerging paradigms of molecular signaling governing the dermal papilla-epithelial cellular interactions during hair growth and maintenance and the recent progress made towards tissue engineering of human hair follicles"
Keywords:		Animals Dermis/*physiology Hair Follicle/*physiology Humans Mice Regeneration/*physiology Skin/injuries/physiopathology Stem Cells/*physiology Wound Healing/physiology Follicle Hair growth Hypoxia-inducible factor pathway Regeneration Stem cells Wnt beta-;
Notes:		"MedlineHouschyar, Khosrow Siamak Borrelli, Mimi R Tapking, Christian Popp, Daniel Puladi, Behrus Ooms, Mark Chelliah, Malcolm P Rein, Susanne Pforringer, Dominik Thor, Dominik Reumuth, Georg Wallner, Christoph Branski, Ludwik K Siemers, Frank Grieb, Gerrit Lehnhardt, Marcus Yazdi, Amir S Maan, Zeshaan N Duscher, Dominik eng Review Switzerland 2020/03/13 Dermatology. 2020; 236(4):271-280. doi: 10.1159/000506155. Epub 2020 Mar 12"