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Bioanalysis

Title:		Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer
Author(s):		Heaney LM; Ruszkiewicz DM; Arthur KL; Hadjithekli A; Aldcroft C; Lindley MR; Thomas CP; Turner MA; Reynolds JC;
Address:		"Centre for Analytical Science, Department of Chemistry, Loughborough University, Epinal Way, Loughborough, Leicestershire LE11 3TU, UK. School of Sport, Exercise & Health Sciences, Loughborough University, Epinal Way, Loughborough, Leicestershire LE11 3TU, UK. Department of Cardiovascular Sciences & NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK. Advion UK Ltd, Edinburgh Way, Harlow CM20 2NQ, UK"
Journal Title:		Bioanalysis
Year:		2016
Volume:		20160609
Issue:		13
Page Number:		1325 - 1336
DOI:		10.4155/bio-2016-0045
ISSN/ISBN:		1757-6199 (Electronic) 1757-6180 (Linking)
Abstract:		"AIM: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. CONCLUSION: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time"
Keywords:		Adult Atmospheric Pressure Breath Tests/*instrumentation Equipment Design Exhalation Female Humans Male Mass Spectrometry/*instrumentation Mentha piperita Menthol/*analysis/metabolism Middle Aged Plant Oils/administration & dosage/*analysis/metabolism Poi;
Notes:		"MedlineHeaney, Liam M Ruszkiewicz, Dorota M Arthur, Kayleigh L Hadjithekli, Andria Aldcroft, Clive Lindley, Martin R Thomas, Cl Paul Turner, Matthew A Reynolds, James C eng England 2016/06/10 Bioanalysis. 2016 Jul; 8(13):1325-36. doi: 10.4155/bio-2016-0045. Epub 2016 Jun 9"