| Title: | Induction of yeast mating pheromone a-factor by alpha cells |
| ISSN/ISBN: | 0028-0836 (Print) 0028-0836 (Linking) |
| Abstract: | "Saccharomyces cerevisiae cells of a and alpha mating types constitutively secrete cell-specific peptide mating pheromones. a-Factor is secreted by a cells and acts on alpha cells, while alpha-factor is secreted by alpha cells and acts on a cells. Confirming preliminary studies, we demonstrate here that cultures of a cells contain higher than constitutive levels of a-factor activity when grown with alpha cells or alpha-factor. This induction of a-factor may result from increased synthesis or increased secretion of a-factor, as opposed to modification or stabilization of preexisting a-factor, as part of the a cell response to alpha-factor, as an a ste2 mutant (which cannot respond to alpha-factor) is not induced by alpha-factor. In mixed cultures inoculated with equal numbers of a cells and alpha cells, a cells predominate by stationary phase. Thus, a series of sequential interactions between a and alpha cells may be involved in establishing optimal hormone concentrations and cell ratios for conjugation" |
| Keywords: | Animals Cell Communication Fungal Proteins/biosynthesis Mating Factor *Peptide Biosynthesis *Peptides Pheromones/*physiology Saccharomyces cerevisiae/*physiology; |
| Notes: | "MedlineStrazdis, J R MacKay, V L eng GM22149/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 1983/10/06 Nature. 1983 Oct 6-12; 305(5934):543-5. doi: 10.1038/305543a0" |
