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Philos Trans R Soc Lond B Biol Sci

Title:		Feedback regulation of map kinase signal pathways
Author(s):		Errede B; Ge QY;
Address:		"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill 27599-7260, USA"
Journal Title:		Philos Trans R Soc Lond B Biol Sci
Year:		1996
Volume:		351
Issue:		1336
Page Number:		143 - 148
DOI:		10.1098/rstb.1996.0010
ISSN/ISBN:		0962-8436 (Print) 0962-8436 (Linking)
Abstract:		Ste7 is a MEK (MAPK/ERK kinase) family member that functions in the pheromone induced mating response pathway of Saccharomyces cerevisiae. We analysed the catalytic competence and in vivo function of Ste7 variants that have alterations of stimulatory and feedback phosphorylation sites. These analyses led us to unanticipated insights into two separate feedback mechanisms that impede the output of the mating response MAPK activation pathway
Keywords:		Calcium-Calmodulin-Dependent Protein Kinases/physiology Feedback/physiology Protein Serine-Threonine Kinases/*physiology Signal Transduction/*physiology Yeasts/enzymology;
Notes:		"MedlineErrede, B Ge, Q Y eng GM-39852/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. Review England 1996/02/29 Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):143-8; discussion 148-9. doi: 10.1098/rstb.1996.0010"