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Pulm Ther

Title:		Asthma Diagnosis: The Changing Face of Guidelines
Author(s):		Drake SM; Simpson A; Fowler SJ;
Address:		"Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK. Sarah.drake@postgrad.manchester.ac.uk. Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK. Sarah.drake@postgrad.manchester.ac.uk. Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK. Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK"
Journal Title:		Pulm Ther
Year:		2019
Volume:		20190701
Issue:		2
Page Number:		103 - 115
DOI:		10.1007/s41030-019-0093-y
ISSN/ISBN:		2364-1746 (Electronic) 2364-1754 (Print) 2364-1754 (Linking)
Abstract:		"Asthma, the most common chronic respiratory disease, is frequently misdiagnosed, and accounts for a significant proportion of healthcare expenditure. This has driven the National Institute for Health and Care Excellence (NICE) in the United Kingdom (UK) to produce recent guidance; in places, this contrasts to that of the British Thoracic Society/Scottish Intercollegiate Guideline Network (BTS/SIGN), which have been producing their own guidance since 2003. Here we review the history of asthma diagnostic guidelines, and compare and review the evidence behind them, in adults and in children. We discuss the definitions of asthma and how these drive the concepts behind diagnostic strategies. We anticipate future directions in asthma diagnosis which will take into account the concepts of personalised medicine and disease endotypes. We also consider the utility of tests in use now and in the future, in particular novel tests relating to small airway inflammation and obstruction"
Keywords:		Asthma Diagnosis Endotype Guidelines Impulse oscillometry (IOS) Multiple-breath washout (MBW) Paediatric Phenotype Treatable trait Volatile organic compounds (VOCs);
Notes:		"PubMed-not-MEDLINEDrake, Sarah M Simpson, Angela Fowler, Stephen J eng Review 2020/02/07 Pulm Ther. 2019 Dec; 5(2):103-115. doi: 10.1007/s41030-019-0093-y. Epub 2019 Jul 1"