| Title: | Cytogenotoxicity of the aqueous extract of Parquetina nigrescens leaf using Allium cepa assay |
| Author(s): | Alabi OA; Atanda HC; Olumurewa JAV; |
| Address: | "Department of Biology, Federal University of Technology, Akure, Ondo State, Nigeria. alabiokunola@yahoo.com. Department of Biotechnology, Federal University of Technology, Akure, Ondo State, Nigeria. alabiokunola@yahoo.com. Department of Biotechnology, Federal University of Technology, Akure, Ondo State, Nigeria" |
| DOI: | 10.1007/s00709-022-01741-6 |
| ISSN/ISBN: | 1615-6102 (Electronic) 0033-183X (Linking) |
| Abstract: | "Parquetina nigrescens has been used for decades in ethnomedicine for its antioxidant, antimicrobial, anti-inflammatory, analgesic, and aphrodisiac properties. In this study, the cytotoxic and genotoxic effect of aqueous crude leaf extracts of P. nigrescens on the root meristematic cells of Allium cepa was examined. Volatile organic compounds (VOCs) present in the plant extract were also identified using gas chromatography-mass spectrometry (GC-MS). The extract was prepared with tap water as is locally practised by many Nigerians. Onion bulbs were exposed to 1, 5, 10, 20, and 50% concentrations of the extract for the analysis of root growth inhibition and chromosomal aberration. Lead nitrate (10 ppm) and tap water were used as the positive and negative controls, respectively. The result showed cytotoxicity which was observed as statistically significant (p |
| Keywords: | Analgesics/pharmacology Anti-Inflammatory Agents/pharmacology Antioxidants/pharmacology *Aphrodisiacs/pharmacology Chromosome Aberrations DNA Damage Humans Mitotic Index Onions Plant Extracts/chemistry/pharmacology Plant Roots Pyrans/pharmacology *Volatil; |
| Notes: | "MedlineAlabi, Okunola Adenrele Atanda, Halimat Chisom Olumurewa, John A V eng Austria 2022/02/12 Protoplasma. 2022 Nov; 259(6):1417-1425. doi: 10.1007/s00709-022-01741-6. Epub 2022 Feb 10" |
