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Diagn Microbiol Infect Dis

Title:		The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis
Author(s):		Subali AD; Wiyono L; Yusuf M; Zaky MFA;
Address:		"Faculty of Medicine, Universitas Brawijaya, East Java, Indonesia. Electronic address: anitadominiquesubali@gmail.com. Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Faculty of Medicine, Universitas Brawijaya, East Java, Indonesia"
Journal Title:		Diagn Microbiol Infect Dis
Year:		2022
Volume:		20211030
Issue:		2
Page Number:		115589 -
DOI:		10.1016/j.diagmicrobio.2021.115589
ISSN/ISBN:		1879-0070 (Electronic) 0732-8893 (Print) 0732-8893 (Linking)
Abstract:		"COVID-19 is a major problem with an increasing incidence and mortality. The discovery of Volatile Organic Compounds (VOCs) based on breath analysis offers a reliable, rapid, and affordable screening method. This study examined VOC-based breath analysis diagnostic performance for SARS-COV-2 infection compared to RT-PCR. A systematic review was conducted in 8 scientific databases based on the PRISMA guideline. Original English studies evaluating human breaths for COVID-19 screening and mentioning sensitivity and specificity value compared to RT-PCR were included. Six studies were included with a total of 4093 samples from various settings. VOCs-based breath analysis had the cumulative sensitivity of 98.2% (97.5% CI 93.1%-99.6%) and specificity of 74.3% (97.5% CI 66.4%-80.9%). Subgroup analysis on chemical analysis (GC-MS) and pattern recognition (eNose) revealed higher sensitivity in the eNose group. VOC-based breath analysis shows high sensitivity and promising specificity for COVID-19 public screening"
Keywords:		"Breath Tests/*methods COVID-19/*diagnosis Electronic Nose *Gas Chromatography-Mass Spectrometry Humans Mass Screening/methods SARS-CoV-2/isolation & purification Sensitivity and Specificity Volatile Organic Compounds/*analysis COVID-19, screening, diagnos;"
Notes:		"MedlineSubali, Anita Dominique Wiyono, Lowilius Yusuf, Muhammad Zaky, Muhammad Fathi Athallah eng Meta-Analysis Systematic Review 2021/12/09 Diagn Microbiol Infect Dis. 2022 Feb; 102(2):115589. doi: 10.1016/j.diagmicrobio.2021.115589. Epub 2021 Oct 30"