| Title: | Repression of autocrine pheromone signaling leads to fusaric acid over-production |
| Author(s): | Staropoli A; Guastaferro VM; Vinale F; Turra D; Di Costanzo L; Vitale S; |
| Address: | "Institute for Sustainable Plant Protection, National Research Council, Portici, Italy. Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy. Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy" |
| DOI: | 10.1080/14786419.2023.2227992 |
| ISSN/ISBN: | 1478-6427 (Electronic) 1478-6419 (Linking) |
| Abstract: | "Fusaric acid (FA), a picolinic acid derivative, is a natural substance produced by a wide variety of fungal plant pathogens belonging to the Fusarium genus. As a metabolite, fusaric acid exerts several biological activities including metal chelation, electrolyte leakage, repression of ATP synthesis, and direct toxicity on plants, animals and bacteria. Prior studies on the structure of fusaric acid revealed a co-crystal dimeric adduct between FA and 9,10-dehydrofusaric acid. During an ongoing search for signaling genes differentially regulating FA production in the fungal pathogen Fusarium oxysporum (Fo), we found that mutants lacking pheromone expression have an increased production of FA compared to the wild type strain. Noteworthy, crystallographic analysis of FA extracted from Fo culture supernatants showed that crystals are formed by a dimeric form of two FA molecules (1:1 molar stoichiometry). Overall, our results suggest that pheromone signaling in Fo is required to regulate the synthesis of fusaric acid" |
| Keywords: | Fusarium oxysporum Pheromone fusaric acid metabolites synchrotron data; |
| Notes: | "PublisherStaropoli, Alessia Guastaferro, Valentino Maria Vinale, Francesco Turra, David Di Costanzo, Luigi Vitale, Stefania eng England 2023/07/03 Nat Prod Res. 2023 Jul 3:1-5. doi: 10.1080/14786419.2023.2227992" |
