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J Sep Sci

Title:		Recent applications of gas chromatography with high-resolution mass spectrometry
Author(s):		Spanik I; Machynakova A;
Address:		"Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Bratislava, Slovakia"
Journal Title:		J Sep Sci
Year:		2018
Volume:		20171205
Issue:		1
Page Number:		163 - 179
DOI:		10.1002/jssc.201701016
ISSN/ISBN:		1615-9314 (Electronic) 1615-9306 (Linking)
Abstract:		"Gas chromatography coupled to high-resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high-resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semi-volatile organic compounds. Gas chromatography with high-resolution mass spectrometry quantitative analyses was previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards. The introduction of a quadrupole high-resolution time-of-flight mass analyzer broadened interest in this method and novel applications were developed, especially for multi-target screening purposes. This review is focused on the development and the most interesting applications of gas chromatography coupled to high-resolution mass spectrometry towards analysis of environmental matrices, biological fluids, and food safety since 2010. The main attention is paid to various approaches and applications of gas chromatography coupled to high-resolution mass spectrometry for non-target screening to identify contaminants and to characterize the chemical composition of environmental, food, and biological samples. The most interesting quantitative applications, where a significant contribution of gas chromatography with high-resolution mass spectrometry over the currently used methods is expected, will be discussed as well"
Keywords:		"Animals Chemistry Techniques, Analytical Chemistry, Organic Dioxins/chemistry Environmental Monitoring/*methods Equipment Design Fatty Acids/chemistry Food Food Analysis/*methods Gas Chromatography-Mass Spectrometry/*trends Hormones/analysis Humans Hydroc;"
Notes:		"MedlineSpanik, Ivan Machynakova, Andrea eng Review Germany 2017/11/08 J Sep Sci. 2018 Jan; 41(1):163-179. doi: 10.1002/jssc.201701016. Epub 2017 Dec 5"