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Curr Top Dev Biol

Title:		Sex and death
Author(s):		Shi C; Murphy CT;
Address:		"Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ, United States. Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ, United States. Electronic address: ctmurphy@princeton.edu"
Journal Title:		Curr Top Dev Biol
Year:		2021
Volume:		20200929
Issue:
Page Number:		353 - 375
DOI:		10.1016/bs.ctdb.2020.08.004
ISSN/ISBN:		1557-8933 (Electronic) 0070-2153 (Linking)
Abstract:		"Sexual interactions negatively impact health and longevity in many species across the animal kingdom. C. elegans has been established as a good model to study how mating and intense sexual interactions influence longevity of the individuals. In this chapter, we review the most recent discoveries in this field. We first describe the phenotypes caused by intense mating, including shrinking, fat loss, and glycogen loss. We then describe three major mechanisms underlying mating-induced killing: germline activation, seminal fluid transfer, and male pheromone-mediated toxicity. Next, we summarize the current knowledge of genetic pathways involved in regulating mating-induced death, including DAF-9/DAF-12 steroid signaling, Insulin/IGF-1 signaling (IIS), and TOR signaling. Finally, we discuss the possible fitness benefits of mating-induced death. Throughout this review, we compare and contrast mating-induced death between the sexes and among different species in an effort to discuss this phenomenon and underlying mechanisms from the evolutionary perspective. Further investigation using mated C. elegans will improve our understanding of sexual antagonism, as well as the coordination between reproduction and somatic longevity in response to various external signals. Due to the evolutionary conservation in many aspects of mating-induced death, what we learn from a short-lived mated worm could provide new strategies to improve our own fitness and longevity"
Keywords:		"Animals *Caenorhabditis elegans/genetics Female Male *Sexual Behavior, Animal Germline Insulin/IGF-1 signaling Male pheromones Mating-induced death Seminal fluid Sexual antagonism Steroid signaling TOR signaling;"
Notes:		"MedlineShi, Cheng Murphy, Coleen T eng Review 2021/05/17 Curr Top Dev Biol. 2021; 144:353-375. doi: 10.1016/bs.ctdb.2020.08.004. Epub 2020 Sep 29"