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Prog Mol Biol Transl Sci

Title:		Tools for adapting to a complex habitat: G-protein coupled receptors in Trichoderma
Author(s):		Schmoll M; Hinterdobler W;
Address:		"Department of Microbiology and Ecosystem Science, Division of Terrestrial Ecosystem Research, University of Vienna, Vienna, Austria. Electronic address: monika.schmoll@univie.ac.at. MyPilz GmbH, Vienna, Austria"
Journal Title:		Prog Mol Biol Transl Sci
Year:		2022
Volume:		20220706
Issue:		1
Page Number:		65 - 97
DOI:		10.1016/bs.pmbts.2022.06.003
ISSN/ISBN:		1878-0814 (Electronic) 1877-1173 (Linking)
Abstract:		"Sensing the environment and interpretation of the received signals are crucial competences of living organisms in order to properly adapt to their habitat, succeed in competition and to reproduce. G-protein coupled receptors (GPCRs) are members of a large family of sensors for extracellular signals and represent the starting point of complex signaling cascades regulating a plethora of intracellular physiological processes and output pathways in fungi. In Trichoderma spp. current research involves a wide range of topics from enzyme production, light response and secondary metabolism to sexual and asexual development as well as biocontrol, all of which require delicate balancing of resources in response to the environmental challenges or biotechnological needs at hand, which are crucially impacted by the surroundings of the fungi and their intercellular signaling cascades triggering a precisely tailored response. In this review we summarize recent findings on sensing by GPCRs in Trichoderma, including the function of pheromone receptors, glucose sensing by CSG1 and CSG2, regulation of secondary metabolism by GPR8 and impacts on mycoparasitism by GPR1. Additionally, we provide an overview on structural determinants, posttranslational modifications and interactions for regulation, activation and signal termination of GPCRs in order to inspire future in depth analyses of their function and to understand previous regulatory outcomes of natural and biotechnological processes modulated or enabled by GPCRs"
Keywords:		"Humans *Trichoderma/metabolism Receptors, G-Protein-Coupled/metabolism Signal Transduction Ecosystem Cellulase regulation Glucose Hypocrea Light response Mycoparasitism Nutrient sensing Secondary metabolism Sorbicillin Trichoderma;"
Notes:		"MedlineSchmoll, Monika Hinterdobler, Wolfgang eng P 30893/FWF_/Austrian Science Fund FWF/Austria Review Netherlands 2022/11/11 Prog Mol Biol Transl Sci. 2022; 193(1):65-97. doi: 10.1016/bs.pmbts.2022.06.003. Epub 2022 Jul 6"