| Title: | Urinary volatile metabolomics as a viable alternative diagnostic tool for polycystic ovary syndrome: An exploratory hypothesis |
| Author(s): | Sankarganesh D; Suriyakalaa U; Ramachandran R; Achiraman S; Arunachalam S; Angayarkanni J; |
| Address: | "Department of Microbial Biotechnology, Bharathiar University, Coimbatore 641046, India; Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Krishnankoil 626126, India. Department of Microbial Biotechnology, Bharathiar University, Coimbatore 641046, India. Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620024, India. Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Krishnankoil 626126, India. Department of Microbial Biotechnology, Bharathiar University, Coimbatore 641046, India. Electronic address: angaibiotech@buc.edu.in" |
| DOI: | 10.1016/j.mehy.2019.02.009 |
| ISSN/ISBN: | 1532-2777 (Electronic) 0306-9877 (Linking) |
| Abstract: | "Polycystic Ovary Syndrome (PCOS) is a metabolic disorder prevalent globally. Female infertility cases are also on the increase during the recent times which almost matches with the increasing incidence of PCOS. The NIH-USA-defined symptoms for clinical confirmation of PCOS include oligo-ovulation, elevated androgen level and presence of cysts in the ovary. Therapeutic approaches to PCOS require confirmatory diagnostics such as measurement of hormones and ultrasound scan of the ovary, which are in part, invasive. Conversely, the volatile organic compounds (VOCs) that are present in body fluids (urine, feces, saliva, etc.) and exhaled breath are reported to be endogenously altered in diseased state, which may be indicative of diseases including cancer. We hypothesize that the hindered metabolic state in PCOS condition would conditionally alter the VOCs that eventually are excreted in urine, which may offer a template to develop a viable and non-invasive diagnostic tool" |
| Keywords: | "Androgens/urine Animals Biomarkers/*urine Body Fluids/metabolism Estrogens/urine Exhalation Female Humans Incidence Infertility, Female/complications/diagnosis/urine Insulin Resistance Metabolic Syndrome/metabolism Metabolomics/*methods Mice Models, Theor;" |
| Notes: | "MedlineSankarganesh, Devaraj Suriyakalaa, Udhayaraj Ramachandran, Rajamanickam Achiraman, Shanmugam Arunachalam, Sankarganesh Angayarkanni, Jayaraman eng 2019/02/26 Med Hypotheses. 2019 Mar; 124:121-124. doi: 10.1016/j.mehy.2019.02.009. Epub 2019 Feb 2" |
