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Cancers (Basel)

Title:		A Systematic Review and Meta-Analysis: Volatile Organic Compound Analysis in the Detection of Hepatobiliary and Pancreatic Cancers
Author(s):		Pelling M; Chandrapalan S; West E; Arasaradnam RP;
Address:		"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. Department of Gastroenterology, Epsom and St Heliers NHS Trust, Carshalton SM5 1AA, UK. Department of Gastroenterology, University Hospital of Coventry and Warwickshire, Coventry CV2 2DX, UK. Health, Biological & Experimental Sciences, University of Coventry, Coventry CV1 5FB, UK. School of Health Sciences, University of Leicester, Leicester LE1 7RH, UK"
Journal Title:		Cancers (Basel)
Year:		2023
Volume:		20230414
Issue:		8
Page Number:		-
DOI:		10.3390/cancers15082308
ISSN/ISBN:		2072-6694 (Print) 2072-6694 (Electronic) 2072-6694 (Linking)
Abstract:		"BACKGROUND: Hepatobiliary cancers are notoriously difficult to detect, frequently leading to diagnosis in later stages of disease when curative treatment is not an option. The currently used biomarkers such as AFP (alpha-fetoprotein) and CA19.9 lack sensitivity and specificity. Hence, there is an unmet need for an alternative biomarker. AIM: To evaluate the diagnostic accuracy of volatile organic compounds (VOCs) for the detection of hepatobiliary and pancreatic cancers. METHODS: A systematic review of VOCs' use in the detection of hepatobiliary and pancreatic cancers was performed. A meta-analysis was performed using the software R. Heterogeneity was explored through meta-regression analysis. RESULTS: A total of 18 studies looking at 2296 patients were evaluated. Pooled sensitivity and specificity of VOCs for the detection of hepatobiliary and pancreatic cancer were 0.79 (95% CI, 0.72-0.85) and 0.81 (97.5% CI, 0.76-0.85), respectively. The area under the curve was 0.86. Meta-regression analysis showed that the sample media used contributed to heterogeneity. Bile-based VOCs showed the highest precision values, although urine and breath are preferred for their feasibility. CONCLUSIONS: Volatile organic compounds have the potential to be used as an adjunct tool to aid in the early diagnosis of hepatobiliary cancers"
Keywords:		gallbladder cancer hepatocellular cancer pancreatic cancer volatile organic compounds;
Notes:		"PubMed-not-MEDLINEPelling, Melina Chandrapalan, Subashini West, Emily Arasaradnam, Ramesh P eng Review Switzerland 2023/05/16 Cancers (Basel). 2023 Apr 14; 15(8):2308. doi: 10.3390/cancers15082308"