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Reprod Toxicol

Title:		"Parental perinatal exposure to bisphenol A reduces the threshold to disrupt blastocyst implantation via decreasing talin, occudin and E-cadherin levels"
Author(s):		Martinez-Pena AA; Pena-Castillo A; Parra-Forero LY; Hernandez-Ochoa I; Hernandez-Barrientos LR; Morimoto S; Mendoza-Rodriguez CA;
Address:		"Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico 04510, Mexico. Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional (Cinvestav), Ciudad de Mexico 07360, Mexico. Instituto Nacional de Ciencias Medicas y de la Nutricion Salvador Zubiran, Ciudad de Mexico 14080, Mexico. Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico 04510, Mexico. Electronic address: adrimed@yahoo.com"
Journal Title:		Reprod Toxicol
Year:		2019
Volume:		20190424
Issue:
Page Number:		86 - 97
DOI:		10.1016/j.reprotox.2019.04.005
ISSN/ISBN:		1873-1708 (Electronic) 0890-6238 (Linking)
Abstract:		"The aim was to evaluate the effect of perinatal BPA exposure of one or both parents on the implantation index and expression of talin, occludin and E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation day 21. F1 animals were mated forming four groups: Control dam-Control sire (Cfemale symbol-Cmale symbol), BPA dam -Control sire (Bfemale symbol-Cmale symbol), Control dam -BPA sire (Cfemale symbol-Bmale symbol), BPA dam -BPA sire (Bfemale symbol-Bmale symbol). F1 dams were sacrificed at GD 6. Significantly decreased number of implantation sites was observed in the Bfemale symbol-Bmale symbol group as compared to the Cfemale symbol-Cmale symbol group, which correlated with decreased talin apical/basal expression ratio, occludin apical expression, and E-cadherin apical/lateral expression ratio in the UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. Our data suggest that reduced protein expressions in F1 BPA offspring could result from decreased progesterone serum levels"
Keywords:		"Animals Benzhydryl Compounds/*toxicity Cadherins/*metabolism Embryo Implantation/*drug effects Estradiol/blood Female Male *Maternal-Fetal Exchange Occludin/*metabolism Phenols/*toxicity Pregnancy Progesterone/blood Rats, Wistar Talin/*metabolism Uterus/d;"
Notes:		"MedlineMartinez-Pena, Annia A Pena-Castillo, Andrea Parra-Forero, L Yuliana Hernandez-Ochoa, Isabel Hernandez-Barrientos, Luis R Morimoto, Sumiko Mendoza-Rodriguez, C Adriana eng Research Support, Non-U.S. Gov't 2019/04/28 Reprod Toxicol. 2019 Jun; 86:86-97. doi: 10.1016/j.reprotox.2019.04.005. Epub 2019 Apr 24"