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Curr Opin Neurobiol

Title:		Pheromone transduction in the vomeronasal organ
Author(s):		Liman ER;
Address:		"Howard Hughes Medical Institute, Wellman 414, Massachusetts General Hospital, 50 Blossom Street, Boston, 02114, USA. liman@helix.mgh.harvard.edu"
Journal Title:		Curr Opin Neurobiol
Year:		1996
Volume:		6
Issue:		4
Page Number:		487 - 493
DOI:		10.1016/s0959-4388(96)80054-7
ISSN/ISBN:		0959-4388 (Print) 0959-4388 (Linking)
Abstract:		Single-cell physiology and cloning efforts have extended studies of the vomeronasal organ to cellular and molecular levels. Recent work has shown that transduction in the vomeronasal organ is probably mediated by signalling pathways distinct from those that mediate transduction in the main olfactory system. An advance in understanding transduction has come with the cloning from rat vomeronasal organ of a family of putative pheromone receptor genes that bear no sequence similarity to previously cloned receptors. Other work has examined the expression of putative signalling components and found a zonal organization of the epithelium. Patch-clamp studies have described the basic electrical properties of vomeronasal neurons and explored second-messenger pathways
Keywords:		"Animals Carrier Proteins/metabolism Humans Molecular Biology/methods Nasal Cavity/innervation/*physiology Nasal Septum/innervation/*physiology Neurons, Afferent/physiology Pheromones/metabolism/*physiology *Signal Transduction;"
Notes:		"MedlineLiman, E R eng R03 DC 02889-01/DC/NIDCD NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review England 1996/08/01 Curr Opin Neurobiol. 1996 Aug; 6(4):487-93. doi: 10.1016/s0959-4388(96)80054-7"