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Mol Cells

Title:		The regulation of Clb5 kinase activity by mating factor
Author(s):		Jeoung DI; Cross F;
Address:		"The Rockefeller University, New York, New York 10021, USA"
Journal Title:		Mol Cells
Year:		2000
Volume:		10
Issue:		4
Page Number:		460 - 464
DOI:
ISSN/ISBN:		1016-8478 (Print) 1016-8478 (Linking)
Abstract:		"Mating factor was found to affect Clb5 kinase activity in Saccharomyces cerevisiae. Mating factor decreased Clb5 kinase activity in a time- and dose-dependent manner. The regulation of Clb5 kinase activity requires functional CLNs (G1 cyclins). Strains without functional CLNs still showed sensitivity to mating factor in the presence of moderately expressing Clb5. This type of mating factor sensitivity is thought to be induced by non-G1 arrest. It is apparent that mating factor treated cells contained inhibitor(s) of Clb5 kinase activity, suggesting that inhibition of Clb5 kinase activity is accompanied by a specific inhibitor. This notion is supported by mixing experiment. Nocodazole treatment showed that the effect of mating factor on Clb5 kinase activity occurred at G1 and connected to mitotic exit. Mating factor regulation of Clb5 kinase activity was found to be dependent on Sic1 protein"
Keywords:		Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclin-Dependent Kinases/*metabolism Cyclins/genetics/metabolism Fungal Proteins/metabolism G1 Phase Intracellular Signaling Peptides and Proteins Mating Factor Mutation Nocodazole/pharmacolog;
Notes:		"MedlineJeoung, D I Cross, F eng 49716/PHS HHS/ Research Support, U.S. Gov't, P.H.S. Korea (South) 2000/09/15 Mol Cells. 2000 Aug 31; 10(4):460-4"