| Title: | Effect of indoor air quality of day care centers in children with different predisposition for asthma |
| Author(s): | Carreiro-Martins P; Papoila AL; Caires I; Azevedo S; Cano MM; Virella D; Leiria-Pinto P; Teixeira JP; Rosado-Pinto J; Annesi-Maesano I; Neuparth N; |
| Address: | "CEDOC, Respiratory Research Group, Nova Medical School, Campo dos Martires da Patria, Lisbon, Portugal. Servico de Imunoalergologia, Hospital de Dona Estefania, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal. Epidemiology and Statistics Analisys Unit, Research Centre, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal. CEAUL, Department of Biostatistic and Informatics, Nova Medical School, Campo dos Martires da Patria, 130, 1169-056, Lisbon, Portugal. National Laboratory for Civil Engineering, Lisbon, Portugal. Environmental Health Department, National Health Institute Doutor Ricardo Jorge - Lisboa, Lisbon, Portugal. Environmental Health Department, National Health Institute Doutor Ricardo Jorge - Porto, Oporto, Portugal. Institute of Public Health (ISPUP), University of Porto, Oporto, Portugal. Hospital da Luz, Lisbon, Portugal. Sorbonne Universites, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique (IPLESP UMRS 1136), Epidemiology of Allergic and Respiratory diseases department (EPAR), Medical School Saint-Antoine, F75012 Paris, France" |
| ISSN/ISBN: | 1399-3038 (Electronic) 0905-6157 (Linking) |
| Abstract: | "BACKGROUND: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility. METHODS: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants. RESULTS: We included 1191 children, with a median age of 43 (P25 -P75 : 25-58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00-1.20). Each increment of 100 mug/m(3) of total volatile organic compounds (TVOC) and 1 mug of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01-1.11 and OR: 1.06; 95% CI: 0.99-1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00-1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API. CONCLUSIONS: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma" |
| Keywords: | "Air Pollution, Indoor/*adverse effects/analysis Asthma/*etiology *Child Day Care Centers Child, Preschool Disease Susceptibility Female Follow-Up Studies Humans Male Respiratory Sounds/*etiology Risk Factors Surveys and Questionnaires asthma asthma predic;" |
| Notes: | "MedlineCarreiro-Martins, Pedro Papoila, Ana Luisa Caires, Iolanda Azevedo, Susana Cano, Maria Manuela Virella, Daniel Leiria-Pinto, Paula Teixeira, Joao Paulo Rosado-Pinto, Jose Annesi-Maesano, Isabella Neuparth, Nuno eng Clinical Trial, Phase II Research Support, Non-U.S. Gov't England 2015/12/15 Pediatr Allergy Immunol. 2016 May; 27(3):299-306. doi: 10.1111/pai.12521. Epub 2016 Jan 26" |
