| Title: | Ploidy regulation of gene expression |
| Author(s): | Galitski T; Saldanha AJ; Styles CA; Lander ES; Fink GR; |
| Address: | "Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA" |
| DOI: | 10.1126/science.285.5425.251 |
| ISSN/ISBN: | 0036-8075 (Print) 0036-8075 (Linking) |
| Abstract: | "Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiae strains that varied in ploidy from haploid to tetraploid. These genes were induced or repressed in proportion to the number of chromosome sets, regardless of the mating type. Ploidy-dependent repression of some G1 cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression. Moreover, ploidy regulation of the FLO11 gene had direct consequences for yeast development" |
| Keywords: | "Chitinases/genetics Cyclins/genetics Fungal Proteins/genetics G1 Phase *Gene Expression Regulation, Fungal Haploidy Lipoproteins/genetics/physiology Mating Factor Membrane Glycoproteins Membrane Proteins/genetics Oligonucleotide Array Sequence Analysis Pe;" |
| Notes: | "MedlineGalitski, T Saldanha, A J Styles, C A Lander, E S Fink, G R eng GM35010/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1999/07/10 Science. 1999 Jul 9; 285(5425):251-4. doi: 10.1126/science.285.5425.251" |
