« Previous AbstractVariation in Splicing Efficiency Underlies Morphological Evolution in Capsella    Next AbstractPhysical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone response »

Neurosci Lett

Title:		Scopolamine modulates paternal parental retrieval behavior in mice induced by the maternal mate
Author(s):		Fujimoto H; Liu HX; Lopatina O; Brown DA; Higashida H;
Address:		"Department of Basic Research on Social Recognition, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan"
Journal Title:		Neurosci Lett
Year:		2013
Volume:		20130510
Issue:
Page Number:		63 - 66
DOI:		10.1016/j.neulet.2013.04.059
ISSN/ISBN:		1872-7972 (Electronic) 0304-3940 (Linking)
Abstract:		"Appropriate parental care by the father can greatly facilitate healthy human family life. Much less is known from animal studies about the factors leading to paternal parental care than those favoring maternal parent care. Recently, we have reported that sires of the ICR strain of laboratory mice can express maternal-like retrieval behavior when separated from their pups through ultrasound and pheromonal signals from the dam, i.e. mate-dependent parental care. The sire's retrieval behavior was inhibited by prior treatment of scopolamine, a muscarinic cholinergic inhibitor, and recovered by physostigmine. KCNQ K(+)-channel blocking and enhancing drugs, linopiridine and retigabine, were also examined. Linopiridine alone did not enhance care after pairing with the dam, nor change scopolamine-induced inhibition of care. Retigabine totally suppressed parental care, and this effect was partially rescued by co-administration of linopiridine. These results indicate the involvement of cholinergic cellular signaling in the central nervous system in the maternal induction of paternal parental behavior in ICR mice"
Keywords:		"Animals Appetitive Behavior/drug effects/*physiology Cholinergic Antagonists/administration & dosage Cholinergic Neurons/drug effects/*physiology Female Male Maternal Behavior/drug effects/*physiology Mice Mice, Inbred ICR Paternal Behavior/drug effects/*;"
Notes:		"MedlineFujimoto, Hiroko Liu, Hong-Xiang Lopatina, Olga Brown, David A Higashida, Haruhiro eng Research Support, Non-U.S. Gov't Ireland 2013/05/15 Neurosci Lett. 2013 Jun 24; 546:63-6. doi: 10.1016/j.neulet.2013.04.059. Epub 2013 May 10"