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J Chromatogr A

Title:		Sensitive and selective gas chromatography-tandem mass spectrometry method for the detection of nitrobenzene in tobacco smoke
Author(s):		Chapman GM; Bravo R; Stanelle RD; Watson CH; Valentin-Blasini L;
Address:		"Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, United States. Electronic address: xju5@cdc.gov. Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, United States"
Journal Title:		J Chromatogr A
Year:		2018
Volume:		20180611
Issue:
Page Number:		124 - 129
DOI:		10.1016/j.chroma.2018.06.028
ISSN/ISBN:		1873-3778 (Electronic) 0021-9673 (Print) 0021-9673 (Linking)
Abstract:		"Nitrobenzene, a potentially harmful compound found in tobacco smoke, has been largely excluded from prior analysis due to difficulties with quantification. Quantifying harmful compounds in cigarette smoke is useful to compare products, to examine the impact of design parameters on delivery, and to help estimate exposures. A sensitive high-throughput method has been developed for quantifying nitrobenzene in machine-generated mainstream cigarette smoke using isotope dilution gas chromatography-tandem mass spectrometry (ID-GC-MS/MS). This method has sufficient sensitivity to measure vapor phase nitrobenzene concentrations in the low nanogram range, with a 418?ª+pg/cig method limit of detection. Precision estimates from two quality control cigarette products resulted in percent relative standard deviations of 11.5% and 14.9%; product variability estimates from 13 cigarette products resulted in percent relative standard deviations ranging from 2.8% to 16.9%. Nitrobenzene in the machine-generated, mainstream smoke from 15 cigarette products are reported and range from 18 to 38?ª+ng/cig under the Health Canada Intense smoking regimen"
Keywords:		Calibration Canada Gas Chromatography-Mass Spectrometry/*methods Ions Limit of Detection Nitrobenzenes/*analysis Particulate Matter/analysis Reproducibility of Results Tandem Mass Spectrometry Tobacco/*chemistry Tobacco Products/analysis Tobacco Smoke Pol;
Notes:		"MedlineChapman, Gala M Bravo, Roberto Stanelle, Rayman D Watson, Clifford H Valentin-Blasini, Liza eng CC999999/Intramural CDC HHS/ Netherlands 2018/06/28 J Chromatogr A. 2018 Aug 31; 1565:124-129. doi: 10.1016/j.chroma.2018.06.028. Epub 2018 Jun 11"