| Title: | "Transcription factor fork head regulates the promoter of diapause hormone gene in the cotton bollworm, Helicoverpa armigera, and the modification of SUMOylation" |
| Author(s): | Bao B; Hong B; Feng QL; Xu WH; |
| Address: | "State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, China" |
| DOI: | 10.1016/j.ibmb.2011.04.009 |
| ISSN/ISBN: | 1879-0240 (Electronic) 0965-1748 (Linking) |
| Abstract: | "The transcription factor fork head (FoxA) plays important roles in development and metabolism. Here, we cloned a fork head gene in Helicoverpa armigera, and found that the fork head protein is mainly located in the nucleus. This fork head gene belongs to the FoxA subfamily of the Fox transcription factors. The diapause hormone and pheromone biosynthesis-activating neuropeptide (DH-PBAN), which are two well-documented insect neuropeptides that regulate insect development and pheromone biosynthesis, are encoded by a single mRNA. In the present study, fork head was shown to bind strongly to the promoter of H. armigera DH-PBAN gene, and regulate its promoter activity. Furthermore, the effect of SUMOylation of the FH protein on the regulation of Har-DH-PBAN gene was investigated, and we show that the SUMO can modify Har-FH protein and cause down-regulation of DH-PBAN gene expression. These results suggest that SUMOylated FH plays a key role in insect diapause in H. armigera" |
| Keywords: | "Amino Acid Sequence Animals Base Sequence Cloning, Molecular Down-Regulation Forkhead Transcription Factors/*genetics/metabolism Gene Expression Regulation, Developmental Insect Proteins/*genetics/metabolism Molecular Sequence Data Moths/*genetics/growth;" |
| Notes: | "MedlineBao, Bin Hong, Bo Feng, Qi-Li Xu, Wei-Hua eng Research Support, Non-U.S. Gov't England 2011/05/18 Insect Biochem Mol Biol. 2011 Sep; 41(9):670-9. doi: 10.1016/j.ibmb.2011.04.009. Epub 2011 May 7" |
