| Title: | Characterization of gait and olfactory behaviors in the Balb/c mouse model of autism spectrum disorders |
| Author(s): | Burket JA; Young CM; Green TL; Benson AD; Deutsch SI; |
| Address: | "Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, United States. Muhlenberg College, Allentown, PA, United States. Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA, United States. Electronic address: deutscsi@evms.edu" |
| DOI: | 10.1016/j.brainresbull.2016.02.017 |
| ISSN/ISBN: | 1873-2747 (Electronic) 0361-9230 (Linking) |
| Abstract: | "Abnormalities of gait and olfaction have been reported in persons with autism spectrum disorders (ASDs), which could reflect involvement of the cerebellum and nodes related to olfaction (e.g., olfactory bulb and ventral temporal olfactory cortex) in neural circuits subserving social, cognitive, and motor domains of psychopathology in these disorders. We hypothesized that the Balb/c mouse model of ASD would express 'abnormalities' of gait and olfaction, relative to the Swiss Webster comparator strain. Contrary to expectation, Balb/c and Swiss Webster mice did not differ in terms of quantitative measurements of gait and mouse rotarod behavior, and Balb/c mice displayed a shorter latency to approach an unscented cotton swab, suggesting that there was no disturbance of its locomotor behavior. However, Balb/c mice showed significant inhibition of locomotor activity in the presence of floral scents, including novel and familiar floral scents, and a socially salient odor (i.e., concentrated mouse urine); the inhibitory effect on the locomotor behavior of the Balb/c mouse was especially pronounced with the salient social odor. Unlike the Swiss Webster strain, mouse urine lacks social salience for the Balb/c mouse strain, a model of ASD, which does not appear to be an artifact of diminished olfactory sensitivity or impaired locomotion" |
| Keywords: | "Animals Autism Spectrum Disorder/*physiopathology Behavior, Animal/drug effects Cerebellum/physiopathology Disease Models, Animal Gait/*physiology Locomotion/drug effects Male Mice Mice, Inbred BALB C Olfactory Bulb/physiopathology Smell/*physiology Socia;" |
| Notes: | "MedlineBurket, Jessica A Young, Chelsea M Green, Torrian L Benson, Andrew D Deutsch, Stephen I eng 2016/02/27 Brain Res Bull. 2016 Apr; 122:29-34. doi: 10.1016/j.brainresbull.2016.02.017. Epub 2016 Feb 23" |
