| Title: | Changes in the Chemical Components of Processed Rehmanniae Radix Distillate during Different Steaming Times |
| Author(s): | Xue S; Fu Y; Sun X; Chen S; |
| Address: | "School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China" |
| Journal Title: | Evid Based Complement Alternat Med |
| ISSN/ISBN: | 1741-427X (Print) 1741-4288 (Electronic) 1741-427X (Linking) |
| Abstract: | "Distillate was obtained in different processing cycles of processed Rehmanniae Radix (PRR). In this study, we investigated the chemical compositions of distillates 1 (Dis1) to 9 (Dis9) via GC-MS and LC-MS. Differences between Dis1-Dis9 were noticeable. A total of 13 and 21 compounds were detected via GC-MS and LC-MS, respectively, including organic acids, furans, alcohols, iridoid glycosides, phenylpropanoid glycosides, and saccharides. The relative contents of compound 2,5-hydroxymethylfurfural and furans all gradually increased with steaming time. Other compounds, however, exhibited a negative trend or fluctuated. Of these compounds, iridoid glycosides and phenylpropanoid glycosides were unstable and easily degraded, which led to a gradually decreasing concentration with increased steaming times. In addition, the degradation products were mainly derived from catalpol and acteoside, among which catalpol mainly existed as aglycone and its rearranged products. However, acteoside was converted into verbasoside through the removal of caffeoyl. Some volatile alcohols, such as phenylethyl alcohol, hydroxyphenyl ethanol, and 3-hydroxy-4-methoxybenzoic acid, were also likely from the degradation of acteoside and its homologs. These results provide an important reference basis for the processing methods, quality evaluation, and rational clinical application of PRR and its distillate" |
| Notes: | "PubMed-not-MEDLINEXue, Shujuan Fu, Yu Sun, Xiaoya Chen, Suiqing eng 2022/03/01 Evid Based Complement Alternat Med. 2022 Feb 17; 2022:3382333. doi: 10.1155/2022/3382333. eCollection 2022" |
